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miR-21 promotes the fibrotic properties in oral mucosa through targeting PDCD4

Yi-Wen Liao, Lo-Lin Tsai, Yu-Hsien Lee, Pei-Ling Hsieh, ,
Published: 15 September 2021

Abstract: Oral submucous fibrosis (OSF) has been regarded as a premalignant disorder of oral cancer, and myofibroblasts are the main cells that are responsible for pathological fibrosis. Hence, elucidation of the molecular mechanism underlying myofibroblast activation is important to treat OSF. MicroRNA-21 (miR-21) is a well-known fibrosis non-coding RNA, and its role in the development of OSF remains largely unclear.
Keywords: MicroRNA-21 / Myofibroblast / Oral submucous fibrosis / Programmed cell death 4

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