ABSTRAK Neonatus BBLR mempunyai proporsi 20% dari seluruh angka kelahiran bayi di dunia dan sering mengalami stress yang dimanifestasikan dengan peningkatan denyut jantung dan respirasi serta penurunan saturasi oksigen. Diperlukan terapi stimulasi yang dapat menunjang tumbuh kembangnya. Terapi suara dapat memberikan ketenangan bagi neonatus, sejauh ini belum diketahui pengaruh suara sholawat bagi neonatus BBLR. Penelitian ini bertujuan melihat pengaruh suara sholawat terhadap denyut jantung, respirasi dan saturasi oksigen pada neonatus BBLR. Metode penelitian menggunakan Pra Experimental One Group Pra-Post Test Design dilakukan pada 15 subjek dan dipilih secara purposif sampling dari Oktober hingga Desember 2018. Instrumen yang digunakan MP3 berisi suara sholawat Simtubdhurar berdurasi 40 menit diperdengarkan melalui speaker dengan maksimal suara yang sampai ke subjek 60 desibel di ukur dengan sound level meter. Nilai rerata denyut jantung dan respirasi setelah mendapat perlakuan menunjukkan penurunan dan peningkatan saturasi oksigen. Terdapat penurunan yang signifikan pada denyut nadi (Sig. (2-tailed)= 0,001) dan respirasi (Asymp. Sig. (2-tailed)= 0,009) serta peningkatan saturasi oksigen (Asymp. Sig. (2-tailed)= 0,004) pada hari ketiga perlakuan. Suara sholawat mempunyai pengaruh terhadap denyut nadi, respirasi dan saturasi oksigen pada neonatus BBLR. Suara sholawat dapat dijadikan pilihan terapi komplementer selama menjalani perawatan di ruang NICU. Keywords : Sound therapy, low birth weight, sholawatABSTRACTLBW neonates have a proportion of 20% of all infant birth rates in the world and often experience stress that is manifested by increased heart rate and respiration and decreased oxygen saturation. Stimulation therapy is needed that can support growth and development. Sound therapy can provide peace for the neonate, so far there is no known sound effect of sholawat for LBW neonates. This study aims to look at the sound effect of sholawat on heart rate, respiration and oxygen saturation in LBW neonates. The research method using Pre Experimental One Group Pre-Post Test Design was carried out on 15 infants treated at the NICU and used purposive sampling technique from October to December 2018. The instruments used by MP3s containing the sound were Simtubdhurar prayer 40 minutes of playing through speakers with maximum sound get to the subject of 60 decibels measured by a sound level meter. The mean heart rate and respiration after receiving treatment showed a decrease and increase in oxygen saturation. There was a significant decrease in pulse (Sig. (2-tailed)= 0.001) and respiration (Asymp. Sig. (2-tailed)= 0.009) and increased oxygen saturation (Asymp. Sig. (2-tailed)= 0.004) on the third day of treatment. The sound of prayer has an influence on pulse, respiration and oxygen saturation in LBW neonates. Sholawat sounds can be a choice of complementary therapies while undergoing treatment in the NICU room.Keywords : Sound therapy, low birth weight, sholawat