High Prevalence of Undocumented SARS-CoV-2 Infections in the Pediatric Population of the Tyrolean District of Schwaz
Open Access
- 19 October 2022
- Vol. 14 (10), 2294
- https://doi.org/10.3390/v14102294
Abstract
Complementing the adult seroprevalence data collected at the time of the rapid SARS-CoV-2 mass vaccination in the district of Schwaz in 2021, we set out to establish the seroprevalence of SARS-CoV-2 among the pediatric population of the district. A total of 369 children, mean age 9.9 (SD 3.4), participated in the study, answering a structured questionnaire on the history of SARS-CoV-2 infection, household contacts, symptoms and history of vaccination. We determined binding and neutralizing antibody levels using plasma samples provided. We estimated the overall prevalence of SARS-CoV-2 infection in the general pediatric population at the time of the study using the census data from Statistik Austria and daily reports of officially confirmed cases. Excluding study participants who reported a history of PCR-confirmed infection, the age-standardized seroprevalence of previously unknown SARS-CoV-2 infection among the general pediatric population of the district was 27% (95% CI: 26.1–27.8). Adding this to the officially documented cases, the true overall prevalence was 32.8% (95% CI: 31.9–33.6) in contrast to the officially documented 8.0% (95% CI: 7.5–8.5) by June 2021. This translated into a proportion of 75.7% (95% CI: 74.4–77.0) of cases being officially undocumented, suggesting a high extent of silent SARS-CoV-2 infections in the pediatric population and possibly silent transmission.Keywords
This publication has 54 references indexed in Scilit:
- Nasal Gene Expression of Angiotensin-Converting Enzyme 2 in Children and AdultsJAMA, 2020
- Epidemiology of COVID-19 Among Children in ChinaPEDIATRICS, 2020
- SARS-CoV-2 (COVID-19): What Do We Know About Children? A Systematic ReviewClinical Infectious Diseases, 2020
- SARS-CoV-2 Infection in ChildrenThe New England Journal of Medicine, 2020
- Systematic review of COVID‐19 in children shows milder cases and a better prognosis than adultsActa Paediatrica, 2020
- Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, ChinaJAMA, 2020
- Coronavirus Infections in Children Including COVID-19The Pediatric Infectious Disease Journal, 2020
- Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort studyThe Lancet, 2020
- A Case Series of Children With 2019 Novel Coronavirus Infection: Clinical and Epidemiological FeaturesClinical Infectious Diseases, 2020
- Pseudotype Neutralization Assays: From Laboratory Bench to Data AnalysisMethods and Protocols, 2018