Role of Extracellular Trap Release During Bacterial and Viral Infection
Open Access
- 26 January 2022
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Microbiology
- Vol. 13, 798853
- https://doi.org/10.3389/fmicb.2022.798853
Abstract
Neutrophils are innate immune cells that play an essential role during the clearance of pathogens that can release chromatin structures coated by several cytoplasmatic and granular antibacterial proteins, called neutrophil extracellular traps (NETs). These supra-molecular structures are produced to kill or immobilize several types of microorganisms, including bacteria and viruses. The contribution of the NET release process (or NETosis) to acute inflammation or the prevention of pathogen spreading depends on the specific microorganism involved in triggering this response. Furthermore, studies highlight the role of innate cells different from neutrophils in triggering the release of extracellular traps during bacterial infection. This review summarizes the contribution of NETs during bacterial and viral infections, explaining the molecular mechanisms involved in their formation and the relationship with different components of such pathogens.Funding Information
- Fondo Nacional de Desarrollo Científico y Tecnológico (1190830, 11706964)
- Instituto Milenio en Inmunología e Inmunoterapia (ICN09_016 (P09/016-F))
- Fondo de Innovación para la Competitividad (FIC-R 2017 (BIP Code: 30488811-0))
This publication has 190 references indexed in Scilit:
- Mycobacterium tuberculosis Exploits Human Interferon γ to Stimulate Macrophage Extracellular Trap Formation and NecrosisThe Journal of Infectious Diseases, 2013
- Eosinophil and neutrophil extracellular DNA traps in human allergic asthmatic airwaysJournal of Allergy and Clinical Immunology, 2011
- Statins Enhance Formation of Phagocyte Extracellular TrapsCell Host & Microbe, 2010
- Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular trapsThe Journal of cell biology, 2010
- PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular trapsThe Journal of Experimental Medicine, 2010
- NETs: a new strategy for using old weaponsTrends in Immunology, 2009
- Extracellular histones are major mediators of death in sepsisNature Medicine, 2009
- Netting neutrophils in autoimmune small-vessel vasculitisNature Medicine, 2009
- Leishmania amazonensispromastigotes induce and are killed by neutrophil extracellular trapsProceedings of the National Academy of Sciences of the United States of America, 2009
- Novel cell death program leads to neutrophil extracellular trapsThe Journal of cell biology, 2007