Ameliorative Potential of Aminophylline In Restrain Stress Induced Behavioural and Biochemical Alterations
Open Access
- 2 November 2017
- journal article
- Published by Chitkara University Publications in Journal of Pharmaceutical Technology, Research and Management
- Vol. 5 (2), 117-133
- https://doi.org/10.15415/jptrm.2017.52008
Abstract
This study is designed to investigate the attenuating prospective of aminophylline in immobilization stress generated behavioural changes in rats. Animals were exposed to restrain stress before being subjected to varying doses of aminophylline (1mg/kg, 2mg/kg and 4mg/kg). Behavioural changes were analyzed to assess the intensity and the degree of the stress, by estimating the changes in the exploratory behaviour, spontaneous activity and social behaviour using various paradigms. As a consequence of stress, the behavioral patterns so changed were assessed in the terms of changes in the locomotor activity, number of head dips and increased avoidance behaviour. Aminophylline (4mg/kg) modulated the stress produced changes in the behaviour and oxidative stress generated biochemical alterations in a significant manner (p<0.001). The results so obtained suggest that upon exposure to stress, animal behavioural patterns, biochemical markers levels changed and these changes wereefficiently modulated by aminophylline at therapeutic doses.Keywords
This publication has 22 references indexed in Scilit:
- Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major DepressionBiological Psychiatry, 2009
- The exploratory behaviour of rats in the hole-board apparatus: Is head-dipping a valid measure of neophilia?Behavioural Processes, 2008
- Neonatal and juvenile stress induces changes in adult social behavior without affecting cognitive functionBehavioural Brain Research, 2008
- Lipopolysaccharide and a social stressor influence behaviour, corticosterone and cytokine levels: Divergent actions in cyclooxygenase-2 deficient mice and wild type controlsJournal of Neuroimmunology, 2008
- Behavioral profiles and stress-induced corticosteroid secretion in male Wistar rats subjected to short and prolonged periods of maternal separationHormones and Behavior, 2006
- Antioxidants and Prevention of Chronic DiseaseCritical Reviews in Food Science and Nutrition, 2004
- Immobilization stress-induced changes in brain acetylcholinesterase activity and cognitive function in micePharmacological Research, 2000
- Theophylline: Recent Advances in the Understanding of Its Mode of Action and Uses in Clinical PracticeMayo Clinic Proceedings, 1998
- An Updated Role for Nerve Growth Factor in Neurobehavioural Regulation of Adult VertebratesProgress in Neurobiology, 1993
- NGF and cholinergic control of behavior: anticipation and enhancement of scopolamine effects in neonatal miceDevelopmental Brain Research, 1991