Intraoperative detection of blood vessels with an imaging needle during neurosurgery in humans
Open Access
- 7 December 2018
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science Advances
- Vol. 4 (12), eaav4992
- https://doi.org/10.1126/sciadv.aav4992
Abstract
Intracranial hemorrhage can be a devastating complication associated with needle biopsies of the brain. Hemorrhage can occur to vessels located adjacent to the biopsy needle as tissue is aspirated into the needle and removed. No intraoperative technology exists to reliably identify blood vessels that are at risk of damage. To address this problem, we developed an “imaging needle” that can visualize nearby blood vessels in real time. The imaging needle contains a miniaturized optical coherence tomography probe that allows differentiation of blood flow and tissue. In 11 patients, we were able to intraoperatively detect blood vessels (diameter, >500 μm) with a sensitivity of 91.2% and a specificity of 97.7%. This is the first reported use of an optical coherence tomography needle probe in human brain in vivo. These results suggest that imaging needles may serve as a valuable tool in a range of neurosurgical needle interventions.Funding Information
- Royal Australasian College of Surgeons
- Australian Research Council (CE140100003)
- Australian Research Council (DP150104660)
- Australian Research Council (DP160104175)
- South Australian Government Department of State Development (Premier’s Research and Industry Fund)
- Western Australian Cancer and Palliative Care Group
This publication has 71 references indexed in Scilit:
- Flexible transbronchial optical frequency domain imaging smart needle for biopsy guidanceBiomedical Optics Express, 2012
- Refractive index measurement of acute rat brain tissue slices using optical coherence tomographyOptics Express, 2012
- Pitfalls in precision stereotactic surgerySurgical Neurology International, 2012
- A forward-imaging needle-type OCT probe for image guided stereotactic proceduresOptics Express, 2011
- Intravascular Optical Imaging Technology for Investigating the Coronary ArteryJACC: Cardiovascular Imaging, 2011
- Optical Coherence Tomography: History, Current Status, and Laboratory WorkInvestigative Ophthalmology & Visual Science, 2011
- Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured AdultsNeurocritical Care, 2009
- Correlation of diagnostic yield of stereotactic brain biopsy with number of biopsy bits and site of the lesionBrain Tumor Pathology, 2006
- Intra-operative 3D ultrasound in neurosurgeryActa Neurochirurgica, 2005
- Haemorrhagic complications and the incidence of asymptomatic bleeding associated with stereotactic brain biopsiesActa Neurochirurgica, 2005