Iron(II)‐Catalyzed Aerobic Biomimetic Oxidation of N‐Heterocycles
Open Access
- 6 September 2021
- journal article
- research article
- Published by Wiley in Chemistry – A European Journal
- Vol. 27 (55), 13725-13729
- https://doi.org/10.1002/chem.202102483
Abstract
Herein, an iron(II)-catalyzed biomimetic oxidation of N-heterocycles under aerobic conditions is described. The dehydrogenation process, involving several electron-transfer steps, is inspired by oxidations occurring in the respiratory chain. An environmentally friendly and inexpensive iron catalyst together with a hydroquinone/cobalt Schiff base hybrid catalyst as electron-transfer mediator were used for the substrate-selective dehydrogenation reaction of various N-heterocycles. The method shows a broad substrate scope and delivers important heterocycles in good-to-excellent yields.Funding Information
- Vetenskapsrådet (2019-04042)
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