Synthesis, spectroscopic characterization, crystal structure and pharmacological properties of some novel thiophene-thiourea core derivatives
Open Access
- 30 September 2010
- journal article
- Published by European Journal of Chemistry in European Journal of Chemistry
- Vol. 1 (3), 221-227
- https://doi.org/10.5155/eurjchem.1.3.221-227.124
Abstract
This article presents our research concerning the synthesis of new thiophene-thiourea derivatives (1-12) and their pharmacological properties. These novel thiophene-thiourea derivatives were synthesized and characterized by IR, 1H and 13C NMR spectroscopy, mass spectrometry and elemental analysis. The crystal structure of N,N-diphenyl-N'-(thiophene-2-carbonyl)-thiourea was determined from single crystal X-ray diffraction data. It crystallizes in the monoclinic space group P21 with unit cell dimensions of a=11.7469(5) Å, b=6.0849(2) Å, c=12.5792(6) Å, β= 117.736(7) ° and V = 795.8(6) Å3. The mass fragmentation pattern has also been discussed. The synthesized compounds were screened for their in vitro antifungal activities against the standard strains: C. Albicans, C. Glabrata, and C. Tropicalis. The compounds N-thiophene-N',N'-bis(dimethyl-phosphinoylmethyl)thiourea, N-[(4-nitro-1H-imidazol-2-yl)carbamothioyl]thiophene-2-carboxamide and N,N-diethyl-N'-(thiophene-2-carbonyl)-thiourea showed significant antifungal activities against microbial species.Keywords
This publication has 28 references indexed in Scilit:
- Thermal analysis of 2-oxocyclopentanedithiocarboxylato complexes of iron(iii), copper(ii) and zinc(ii) containing pyridine or morpholine as the second ligandJournal of Thermal Analysis and Calorimetry, 2008
- Synthesis, characterization and thermal behavior of 1,1-dialkyl-3-(4-(3,3-dialkylthioureidocarbonyl)-benzoyl)thiourea and its Cu(II), Ni(II), and Co(II) complexesRussian Journal of Coordination Chemistry, 2006
- Synthesis, characterization and antimicrobial activities of transition metal complexes of N,N -dialkyl- N′ -(2-chlorobenzoyl)thiourea derivativesJournal of Coordination Chemistry, 2006
- A Novel Entry toward 2-Imino-1,3-thiazolidines and 2-Imino-1,3-thiazolines by Ring Transformation of 2-(Thiocyanomethyl)aziridinesThe Journal of Organic Chemistry, 2004
- Synthesis and characterization of copper(II), nickel(II) and cobalt(II) complexes with novel thiourea derivativesTransition Metal Chemistry, 2003
- Thiourea monoanion and dianion complexes of rhodium(III) and ruthenium(II)Inorganica Chimica Acta, 2002
- Synthesis, characterisation and coordination chemistry of novel chiral N,N-dialkyl-N ′-menthyloxycarbonylthioureas. Crystal and molecular structures of N,N-diethyl-N ′-(−)-(3R)-menthyloxycarbonylthiourea and cis-(S,S)-[Pt(L)Cl(DMSO)] [where HL = N-(+)-(3R)-menthyloxycarbonyl-N′-morpholinothiourea or N-benzoyl-N′,N′-diethylthiourea]J. Chem. Soc., Dalton Trans., 2000
- Structural Factors that Influence the Course of Overall [2 + 2] Cycloaddition Reactions between Imidozirconocene Complexes and HeterocumulenesOrganometallics, 2000
- Rhenium(V) Oxo Complexes of Novel N2S2 Dithiourea (DTU) Chelate Ligands: Synthesis and Structural CharacterizationInorganic Chemistry, 1996
- Thiadiazatrimethylenemethane and N,N′,P-triphenylphosphonothioic diamide complexes of platinum(II)J. Chem. Soc., Dalton Trans., 1992