Worldwide trend in human papillomavirus–attributable cancer incidence rates between 1990 and 2012 and Bayesian projection to 2030
- 11 May 2021
- Vol. 127 (17), 3172-3182
- https://doi.org/10.1002/cncr.33628
Abstract
Background There is a paucity of global comparative trend analyses of all human papillomavirus (HPV)–attributable cancers. In addition, most analyses by international sources only describe past trends; few studies have projected the future trend of HPV-attributable cancers. Methods Data were used from the Cancer Incidence in Five Continents (CI5plus) database that contains annual incidence by cancer site, age, and sex, as well as corresponding populations. Age-standardized HPV-attributable cancer incidence rates were calculated and plotted from 1990 through 2012. A Bayesian age-period-cohort model was used to project the HPV-attributable cancer incidence rates of each country up to 2030. Results A significant but small decreasing trend worldwide in the HPV-attributable cancer incidence rate was observed with an average annual percent change (AAPC) of –0.3 (95% CI, –0.6 to –0.1). Notably, Uganda had a consistently increasing trend of HPV-attributable cancer incidence rate, with an AAPC of 1.7 (95% CI, 0.6-2.9). U-shaped trends were observed in some high-income countries because of a recent increase in oral cavity and oropharyngeal cancers. Most countries experience a decreasing or stable trend in HPV-attributable cancers incidence rates between 1990 and 2030. However, Japan, the United Kingdom, the Netherlands, Italy, Costa Rica, and Uganda will have an increasing trend during the projection period. Conclusions Analyses revealed favorable downward trends in HPV-attributable cancer incidence rates in most of the included countries. However, the persistently increasing trend in HPV-attributable cancer incidence rates in Uganda and the recent increase in oral cavity and oropharyngeal cancer incidence rates in some high-income countries may present a new challenge for global HPV-attributable cancer prevention. Lay Summary Analyses revealed favorable downward trends in human papillomavirus (HPV)–attributable cancer incidence rates in most of the included countries. However, the persistently increasing trend in HPV-attributable cancer incidence rates in Uganda and the recent increase in oral cavity and oropharyngeal cancer incidence rates in some high-income countries may present a new challenge for global HPV-attributable cancer prevention.Keywords
Funding Information
- National Natural Science Foundation of China (71904170)
This publication has 36 references indexed in Scilit:
- A Population-Based Study of Visual Inspection With Acetic Acid (VIA) for Cervical Screening in Rural NigeriaInternational Journal of Gynecologic Cancer, 2013
- Cross-protective efficacy of two human papillomavirus vaccines: a systematic review and meta-analysisThe Lancet Infectious Diseases, 2012
- Human Papillomavirus and Rising Oropharyngeal Cancer Incidence in the United StatesJournal of Clinical Oncology, 2011
- Trends in breast, ovarian and cervical cancer incidence in Mumbai, India over a 30-year period, 1976–2005: an age–period–cohort analysisBritish Journal of Cancer, 2011
- Age-Period-Cohort Models in Cancer Surveillance Research: Ready for Prime Time?Cancer Epidemiology, Biomarkers & Prevention, 2011
- Cumulative incidence trends of selected cancer sites in a Philippine population from 1983 to 2002: a joinpoint analysisBritish Journal of Cancer, 2010
- Estimating average annual per cent change in trend analysisStatistics in Medicine, 2009
- Evaluation of data quality in the cancer registry: Principles and methods. Part I: Comparability, validity and timelinessEuropean Journal of Cancer, 2009
- Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysisThe Lancet Infectious Diseases, 2007
- Human papillomavirus as a risk factor for the increase in incidence of tonsillar cancerInternational Journal of Cancer, 2006