New Search

Export article

Canary in the Coal Mine? Male Infertility as a Marker of Overall Health

Nahid Punjani, Dolores J. Lamb
Published: 23 November 2020
Annual Review of Genetics , Volume 54, pp 465-486; doi:10.1146/annurev-genet-022020-023434

Abstract: Male factor infertility is a common problem. Evidence is emerging regarding the spectrum of systemic disease and illness harbored by infertile men who otherwise appear healthy. In this review, we present evidence that infertile men have poor overall health and increased morbidity and mortality, increased rates of both genitourinary and non-genitourinary malignancy, and greater risks of systemic disease. The review also highlights numerous genetic conditions associated with male infertility as well as emerging translational evidence of genitourinary birth defects and their impact on male infertility. Finally, parallels to the overall health of infertile women are presented. This review highlights the importance of a comprehensive health evaluation of men who present for an infertility assessment.
Keywords: DNA repair / birth defects / chromosomal abnormalities / disorders of sexual differentiation / male infertility / systemic disease

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

Share this article

Click here to see the statistics on "Annual Review of Genetics" .
Back to Top Top