Unhealthy foods may attenuate the beneficial relation of a Mediterranean diet to cognitive decline
- 7 January 2021
- journal article
- research article
- Published by Wiley in Alzheimer's & Dementia
- Vol. 17 (7), 1157-1165
- https://doi.org/10.1002/alz.12277
Abstract
Introduction It is unclear whether eating Western diet food components offsets the Mediterranean diet's (MedDiet) potential benefits on cognitive decline. Methods The study includes 5001 Chicago Health and Aging Project participants (63% African American, 36% males, 74 ± 6.0 years old), with food frequency questionnaires and ≥ two cognitive assessments over 6.3 ± 2.8 years of follow‐up. Mixed‐effects models were adjusted for age, sex, education, race, cognitive activities, physical activity, and total calories. Results Stratified analysis showed a significant effect of higher MedDiet on cognitive decline only with a low Western diet score (highest vs lowest MedDiet tertile: β = 0.020, P = .002; p trend = 0.002) and not with a high Western diet score (highest vs lowest MedDiet tertile: β = 0.010, P = .11; p trend = 0.09). Conclusion This prospective study found that high consumption of Western diet components attenuates benefits of the MedDiet on cognition.Keywords
This publication has 47 references indexed in Scilit:
- Adherence to a Mediterranean-type dietary pattern and cognitive decline in a community populationThe American Journal of Clinical Nutrition, 2011
- Deterioration of physical performance and cognitive function in rats with short‐term high‐fat feedingThe FASEB Journal, 2009
- Mediterranean Diet and Mild Cognitive ImpairmentArchives of Neurology, 2009
- Biochemical indicators of vitamin B 12 and folate insufficiency and cognitive declineNeurology, 2009
- High cholesterol‐induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in miceJournal of Neurochemistry, 2008
- Adherence to the Mediterranean food pattern predicts the prevalence of hypertension, hypercholesterolemia, diabetes and obesity, among healthy adults; the accuracy of the MedDietScorePreventive Medicine, 2007
- Associations of vegetable and fruit consumption with age-related cognitive changeNeurology, 2006
- Change in body mass index and risk of incident Alzheimer diseaseNeurology, 2005
- Social resources and cognitive decline in a population of older African Americans and whitesNeurology, 2004
- “Mini-mental state”: A practical method for grading the cognitive state of patients for the clinicianJournal of Psychiatric Research, 1975