Cognitive Changes during Prolonged Stay at High Altitude and Its Correlation with C-Reactive Protein
Open Access
- 5 January 2016
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 11 (1), e0146290
- https://doi.org/10.1371/journal.pone.0146290
Abstract
Hypersensitive C-reaction protein (hsCRP) may be a risk factor for cognitive impairment resulting from Alzheimer’s disease (AD), stroke, and vascular dementia. This study explored the correlation of peripheral blood hsCRP level with cognitive decline due to high altitude exposure. The study was conducted on 100 male military participants who had never been to high altitude. Cerebral oxygen saturation monitoring, event related potentials (P300, N200) detection, and neurocognitive assessment was performed and total hsCRP, interleukin-6 (IL-6), and homocysteine was estimated at 500m altitude, 3650m altitude, 3day, 1, and 3 month post arriving at the base camp (4400m), and 1 month after coming back to the 500m altitude. High altitude increased brain oxygen saturation, prolonged P300 and N200 latencies, injured cognitive functions, and raised plasma hsCRP levels. But they all recovered in varying degrees at 1 and 3 month post arriving at the base camp (4400m). P300 latencies and hsCRP levels were strongly correlated to cognitive performances. These results suggested that cognitive deterioration occurred during the acute period of exposure to high altitude and may recover probably owning to acclimatization after extended stay at high altitude. Plasma hsCRP is inversely correlated to neurological cognition and it may be a potential biomarker for the prediction of high altitude induced cognitive dysfunction.This publication has 36 references indexed in Scilit:
- Effects of acetazolamide on cognitive performance during high-altitude exposureNeurotoxicology and Teratology, 2013
- C-reactive protein is related to memory and medial temporal brain volume in older adultsBrain, Behavior, and Immunity, 2012
- Neurophysiological evidence for cognitive and brain functional adaptation in adolescents living at high altitudeClinical Neurophysiology, 2011
- The cerebral effects of ascent to high altitudesThe Lancet Neurology, 2009
- Homocysteine, Folate and Cognition in a Large Community-Based Sample of Elderly People – The 3C Dijon StudyNeuroepidemiology, 2008
- Inflammatory biomarkers are associated with total brain volumeNeurology, 2007
- Effects of simulated high altitude on event-related potential (P300) and auditory brain-stem responsesClinical Neurophysiology, 2005
- Early inflammation and dementia: A 25‐year follow‐up of the Honolulu‐Asia aging studyAnnals of Neurology, 2002
- Catecholamines, hypoxia and high altitudeActa Physiologica Scandinavica, 1998
- Hypobaric hypoxia impairs spatial memory in an elevation-dependent fashionBehavioral and Neural Biology, 1994