Development of Protein- and Peptide-Based HIV Entry Inhibitors Targeting gp120 or gp41
Open Access
- 1 August 2019
- Vol. 11 (8), 705
- https://doi.org/10.3390/v11080705
Abstract
Application of highly active antiretroviral drugs (ARDs) effectively reduces morbidity and mortality in HIV-infected individuals. However, the emergence of multiple drug-resistant strains has led to the increased failure of ARDs, thus calling for the development of anti-HIV drugs with targets or mechanisms of action different from those of the current ARDs. The first peptide-based HIV entry inhibitor, enfuvirtide, was approved by the U.S. FDA in 2003 for treatment of HIV/AIDS patients who have failed to respond to the current ARDs, which has stimulated the development of several series of protein- and peptide-based HIV entry inhibitors in preclinical and clinical studies. In this review, we highlighted the properties and mechanisms of action for those promising protein- and peptide-based HIV entry inhibitors targeting the HIV-1 gp120 or gp41 and discussed their advantages and disadvantages, compared with the current ARDs.Keywords
Funding Information
- National Natural Science Foundation of China ((81630090 to S.J.; 81672019, 81822045 and 81661128041 to L.L; 81701998 to QW; 81703571 to WX).)
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