Prenatal IgE as a Risk Factor for the Development of Childhood Neurodevelopmental Disorders
Open Access
- 14 May 2021
- journal article
- research article
- Published by Frontiers Media SA in Frontiers in Pediatrics
Abstract
Background: Few studies have examined if maternal allergic disease is associated with an offspring's neurodevelopment. We hypothesized that Th-2 biased maternal immune function assessed as total serum immunoglobulin (Ig) E is associated with attention deficit hyperactivity disorder (ADHD). Methods: Data are from the Wayne County Health, Environment, Allergy, and Asthma Longitudinal Study (WHEALS), a racially and socioeconomically diverse birth cohort in metropolitan Detroit, Michigan. Maternal total IgE was measured prenatally and at 1-month postpartum. Child total IgE was assessed at birth, 6 months, and 2 years of age. ADHD diagnosis was based on the parental report at the 10–12-year study visits or medical chart abstraction. Total IgE was log2 transformed. Poisson regression models with robust error variance were used to calculate the risk ratios (RR). Inverse probability weighting was used to correct for potential bias due to a loss to follow-up and non-response. Results: Of the 636 maternal-child pairs in the analysis, 513 children were neurotypical and 123 had ADHD. Maternal prenatal total IgE was significantly associated with ADHD even after adjustment for potential confounders (RR = 1.08, 95% CI 1.03–1.13). Maternal and child IgE measures were positively and significantly correlated, but child total IgE was not associated with ADHD at any time point. Conclusions: Maternal prenatal IgE may influence neurodevelopment, but additional studies are needed to confirm and expand these findings.This publication has 48 references indexed in Scilit:
- Child health in the United States: Recent trends in racial/ethnic disparitiesSocial Science & Medicine (1982), 2013
- Racial disparities in allergic outcomes in African Americans emerge as early as age 2 yearsClinical & Experimental Allergy, 2011
- Effect of prenatal indoor pet exposure on the trajectory of total IgE levels in early childhoodJournal of Allergy and Clinical Immunology, 2011
- The Prevalence, Severity, and Distribution of Childhood Food Allergy in the United StatesPEDIATRICS, 2011
- Structure and function of immunoglobulinsJournal of Allergy and Clinical Immunology, 2010
- Reduced levels of immunoglobulin in children with autism correlates with behavioral symptomsAutism Research, 2008
- Presence of IgE+ cells in human placenta is independent of malaria infection or chorioamnionitisClinical and Experimental Immunology, 2006
- Cord blood IgE: its determinants and prediction of development of asthma and other allergic disorders at 12 monthsAnnals of Allergy, Asthma & Immunology, 2000
- Early detection of specific IgE antibody against house dust mite in children at risk of allergic diseaseThe Journal of Pediatrics, 1996