Differential dependence of Pavlovian incentive motivation and instrumental incentive learning processes on dopamine signaling
Open Access
- 21 June 2011
- journal article
- Published by Cold Spring Harbor Laboratory in Learning & Memory
- Vol. 18 (7), 475-483
- https://doi.org/10.1101/lm.2229311
Abstract
Here we attempted to clarify the role of dopamine signaling in reward seeking. In Experiment 1, we assessed the effects of the dopamine D1/D2 receptor antagonist flupenthixol (0.5 mg/kg i.p.) on Pavlovian incentive motivation and found that flupenthixol blocked the ability of a conditioned stimulus to enhance both goal approach and instrumental performance (Pavlovian-to-instrumental transfer). In Experiment 2 we assessed the effects of flupenthixol on reward palatability during post-training noncontingent re-exposure to the sucrose reward in either a control 3-h or novel 23-h food-deprived state. Flupenthixol, although effective in blocking the Pavlovian goal approach, was without effect on palatability or the increase in reward palatability induced by the upshift in motivational state. This noncontingent re-exposure provided an opportunity for instrumental incentive learning, the process by which rats encode the value of a reward for use in updating reward-seeking actions. Flupenthixol administered prior to the instrumental incentive learning opportunity did not affect the increase in subsequent off-drug reward-seeking actions induced by that experience. These data suggest that although dopamine signaling is necessary for Pavlovian incentive motivation, it is not necessary for changes in reward experience, or for the instrumental incentive learning process that translates this experience into the incentive value used to drive reward-seeking actions, and provide further evidence that Pavlovian and instrumental incentive learning processes are dissociable.Keywords
This publication has 68 references indexed in Scilit:
- μ-Opioid Receptor Activation in the Basolateral Amygdala Mediates the Learning of Increases But Not Decreases in the Incentive Value of a Food RewardJournal of Neuroscience, 2011
- A selective role for dopamine in stimulus–reward learningNature, 2010
- Phasic Nucleus Accumbens Dopamine Release Encodes Effort- and Delay-Related CostsBiological Psychiatry, 2010
- Dissociable cost and benefit encoding of future rewards by mesolimbic dopamineNature Neuroscience, 2009
- Distinct opioid circuits determine the palatability and the desirability of rewarding eventsProceedings of the National Academy of Sciences of the United States of America, 2009
- The importance of proving the null.Psychological Review, 2009
- Special Review: Decision Utility, The Brain, and Pursuit of Hedonic GoalsSocial Cognition, 2008
- Animal models of depression in dopamine, serotonin, and norepinephrine transporter knockout mice: prominent effects of dopamine transporter deletionsBehavioural Pharmacology, 2008
- Dopamine D1 and D2 receptors in the nucleus accumbens core and shell mediate Pavlovian-instrumental transferLearning & Memory, 2008
- Weighing up the benefits of work: Behavioral and neural analyses of effort-related decision makingNeural Networks, 2006