Effects of agavins in high fat-high sucrose diet-fed mice: an exploratory study
Open Access
- 14 June 2022
- journal article
- research article
- Published by Taylor & Francis Ltd in CyTA - Journal of Food
- Vol. 20 (1), 66-77
- https://doi.org/10.1080/19476337.2022.2082536
Abstract
The present study was to investigate whether agavins supplementation might reduce obesity in mice fed with a high fat-high sucrose (HF-HS) diet. Mice were fed with a HF-HS diet with (HF-HS+A) or without agavins (HF-HS) supplementation. Body weight, white adipose tissue (WAT), biomarkers inflammation, gastrointestinal hormones, microbiota, and their excreted metabolites were evaluated. HF-HS+A mice significantly reduced body weight, WAT, and leptin levels compared to the HF-HS group. Furthermore, pro-inflammatory cytokines and insulin levels tended to be lower in the HF-HS+A group. Moreover, the genera Allobaculum, Akkermansia, and Sutterella, linked with positives effects on host health, were identified as possible biomarkers for agavins treatment; meanwhile, ethyl oleate, thymine, hypoxanthine, uracil, and some fatty acids were substantially enriched with agavins and negative associated with pro-inflammatory biomarkers. Collectively, these results demonstrate that agavins can ameliorates many of the harmful effects induced by intake of a diet with a high fat and sucrose content.Keywords
This publication has 46 references indexed in Scilit:
- Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesityProceedings of the National Academy of Sciences of the United States of America, 2013
- Microbial degradation of complex carbohydrates in the gutGut Microbes, 2012
- Diet high in fat and sucrose induces rapid onset of obesity-related metabolic syndrome partly through rapid response of genes involved in lipogenesis, insulin signalling and inflammation in miceDiabetology & Metabolic Syndrome, 2012
- Circulating Levels of TNF-α Are Associated with Impaired Glucose Tolerance, Increased Insulin Resistance, and Ethnicity: The Insulin Resistance Atherosclerosis StudyJournal of Clinical Endocrinology & Metabolism, 2012
- Metagenomic biomarker discovery and explanationGenome Biology, 2011
- Metabolic Endotoxemia Initiates Obesity and Insulin ResistanceDiabetes, 2007
- Alternative diets for the Pacific white shrimp Litopenaeus vannameiAquaculture, 2007
- Water-Soluble Carbohydrates and Fructan Structure Patterns from Agave and Dasylirion SpeciesJournal of Agricultural and Food Chemistry, 2006
- Obesity alters gut microbial ecologyProceedings of the National Academy of Sciences of the United States of America, 2005
- The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase.JCI Insight, 1995