Synthesis of novel 3,4-dihydroquinoxalin-2(1H)-one derivatives
Open Access
- 30 September 2011
- journal article
- Published by European Journal of Chemistry in European Journal of Chemistry
- Vol. 2 (3), 365-371
- https://doi.org/10.5155/eurjchem.2.3.365-371.289
Abstract
New derivatives of 3,4-dihydroquinoxaline-2(1H)-one were synthesized and characterized. Representative examples were evaluated for their antimicrobial and antifungal activities using Tetracycline and Nystatin as reference compound. One of the tested compounds 10a was found to exhibit slight activity against Staphylococcus aureus. Compounds 10b, 11b and 14b showed slight activity against Escherichia coli. Moreover, nineteen compounds were screened for their inhibition effect on CDK5, CK1, and GSK-3β. None of the tested compounds showed an inhibition activity below 10 µM concentration.Keywords
This publication has 30 references indexed in Scilit:
- Design, synthesis and structure–activity relationship of novel quinoxalin-2-carboxamides as 5-HT3 receptor antagonists for the management of depressionBioorganic & Medicinal Chemistry Letters, 2010
- Synthesis and structure–activity relationship of 3-phenylquinoxaline 1,4-di-N-oxide derivatives as antimalarial agentsEuropean Journal of Medicinal Chemistry, 2008
- In vitro and in vivo anti-tumoral activities of imidazo[1,2-a]quinoxaline, imidazo[1,5-a]quinoxaline, and pyrazolo[1,5-a]quinoxaline derivativesBioorganic & Medicinal Chemistry, 2008
- Synthesis and anti-inflammatory/antioxidant activities of some new ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives and of their 4,5-dihydro-(1H)-pyrazole analoguesBioorganic & Medicinal Chemistry Letters, 2007
- Synthesis and Antimicrobial Activity of Novel Quinoxaline DerivativesJournal of the Chinese Chemical Society, 2007
- Synthesis and antitumor activities of a series of novel quinoxalinhydrazidesBioorganic & Medicinal Chemistry, 2007
- Synthesis of New Quinoxaline-2-carboxylate 1,4-Dioxide Derivatives as Anti-Mycobacterium tuberculosis AgentsJournal of Medicinal Chemistry, 2004
- Synthesis and biological evaluation of 2,3-diarylpyrazines and quinoxalines as selective COX-2 inhibitorsBioorganic & Medicinal Chemistry, 2004
- Synthesis, anti-mycobacterial, anti-trichomonas and anti-candida in vitro activities of 2-substituted-6,7-difluoro-3-methylquinoxaline 1,4-dioxidesEuropean Journal of Medicinal Chemistry, 2004
- Synthesis of certain substituted quinoxalines as antimicrobial agents (Part II).Archives of Pharmacal Research, 2003