Faculty Opinions recommendation of Effectiveness of energy conservation management on fatigue and participation in multiple sclerosis: A randomized controlled trial.
Blikman et al. studied 86 patients with multiple sclerosis (MS) who had significant fatigue to determine the effectiveness of energy conservation management on fatigue and participation. The authors reported the results from a single-blinded randomised control trial of 86 patients with all types of MS (relapsing and progressive) who suffered from significant fatigue as defined by the fatigue domain of the CISr20. Patient-reported outcomes were used to assess fatigue and participation levels at specific time points (final time point 52 weeks). The study did not show any statistically significant differences for fatigue or participation scores between intervention and control at 52 weeks or any other time point. This may have clinical implications as it suggests that in isolation, energy conservation management programs are not effective.