Outcomes and prognostic factors in parotid gland malignancies: A 10‐year single center experience
Open Access
- 13 November 2019
- journal article
- research article
- Published by Wiley in Laryngoscope Investigative Otolaryngology
- Vol. 4 (6), 632-639
- https://doi.org/10.1002/lio2.326
Abstract
Objectives To describe a 10-year single center experience with parotid gland malignancies and to determine factors affecting outcomes. Study Design Retrospective review. Methods The institutional cancer registry was used to identify patients treated surgically for malignancies of the parotid gland between January 2005 and December 2014. Clinical and pathologic data were collected retrospectively from patient charts and analyzed for their association with overall survival (OS) and disease-free survival (DFS). Results Two hundred patients were identified. Mean age at surgery was 57.8 years, and mean follow-up time was 52 months. One hundred two patients underwent total parotidectomy, while 77 underwent superficial parotidectomy, and 21 underwent deep lobe resection. Seventy patients (35%) required facial nerve (FN) sacrifice. Acinic cell carcinoma was the most common histologic type (22%), followed by mucoepidermoid carcinoma (21.5%) and adenoid cystic carcinoma (12.5%). Twenty-nine patients (14.5%) experienced recurrences, with mean time to recurrence of 23.6 months (range: 1-82 months). Five- and 10-year OS were 81% and 73%, respectively. Five- and 10-year DFS were 80% and 73%, respectively. In univariate analyses, age > 60, histologic type, positive margins, high grade, T-stage, node positivity, perineural invasion, and FN involvement were predictors of OS and DFS. In the multivariate analysis, histology, positive margins, node positivity, and FN involvement were independent predictors of OS and DFS. Conclusions Our single-center experience of 200 patients suggests that histology, positive margins, node positivity, and FN involvement are independently associated with outcomes in parotid malignancies. Level of Evidence 4Keywords
This publication has 27 references indexed in Scilit:
- Long-term Outcomes and Quality of Life of 186 Patients With Primary Parotid Carcinoma Treated With Surgery and Radiotherapy at the Daniel den Hoed Cancer CenterEndocrine, 2012
- Fifty years of cancer incidence: CI5 I–IXInternational Journal of Cancer, 2010
- Incidence of Carcinoma of the Major Salivary Glands According to the WHO Classification, 1992 to 2006: A Population-Based Study in the United StatesCancer Epidemiology, Biomarkers & Prevention, 2009
- Cancer of the parotid gland; long-term follow-up. A single centre experience on recurrence and survivalActa Oncologica, 2009
- Treatment and survival outcomes based on histologic grading in patients with head and neck mucoepidermoid carcinomaCancer, 2008
- Deletion of 1p32-p36 Is the Most Frequent Genetic Change and Poor Prognostic Marker in Adenoid Cystic Carcinoma of the Salivary GlandsClinical Cancer Research, 2008
- Prognostic Factors Affecting the Clinical Outcome of Adenoid Cystic Carcinoma of the Head and NeckJapanese Journal of Clinical Oncology, 2007
- Clinical Prognostic Factors in Malignant Parotid Gland TumorsOtolaryngology -- Head and Neck Surgery, 2005
- Trends in incidence and prognosis for head and neck cancer in the United States: A site‐specific analysis of the SEER databaseInternational Journal of Cancer, 2005
- Salivary gland tumoursOral Diseases, 2002