Nonalcoholic Fatty Liver Disease after Liver Transplant
Open Access
- 17 May 2021
- journal article
- review article
- Published by Xia & He Publishing in Journal of Clinical and Translational Hepatology
- Vol. 000 (000), 000
- https://doi.org/10.14218/jcth.2020.00072
Abstract
Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease in the world. The rising prevalence of nonalcoholic steatohepatitis (NASH) has led to a 170% increase in NASH cirrhosis as the listing indication for liver transplantation from 2004 to 2013. As of 2018, NASH has overtaken hepatitis C as an indication for liver transplantation in the USA. After liver transplantation, the allograft often develops recurrent NAFLD among patients with known NASH cirrhosis. In addition to recurrent disease, de novo NAFLD has been reported in patients with other indications for liver transplantation. In this review, we will discuss the risk factors associated with recurrent and de novo NAFLD, natural course of the disease, and management strategies after liver transplantation.Keywords
This publication has 57 references indexed in Scilit:
- Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patientsJournal of Hepatology, 2012
- NAFLD Recurrence in Liver Transplant RecipientsTransplantation, 2011
- Nonalcoholic fatty liver disease after liver transplantation for cryptogenic cirrhosis or nonalcoholic fatty liver diseaseLiver Transplantation, 2009
- Recurrent disease following liver transplantation for nonalcoholic steatohepatitis cirrhosisLiver Transplantation, 2009
- Prevalence and clinical associations of posttransplant fatty liver diseaseLiver International, 2006
- De novo nonalcoholic fatty liver disease after liver transplantationLiver Transplantation, 2006
- Design and validation of a histological scoring system for nonalcoholic fatty liver diseaseJournal of Hepatology, 2005
- Development of nonalcoholic fatty liver disease after orthotopic liver transplantation for cryptogenic cirrhosisLiver Transplantation, 2001
- Posttransplantation Hypertension Related to Calcineurin InhibitorsLiver Transplantation, 2000
- Steatohepatitis: A tale of two “hits”?Gastroenterology, 1998