Mycophenolate Mofetil for Immune Thrombocytopenia
- 2 December 2021
- journal article
- letter
- Published by Massachusetts Medical Society in The New England Journal of Medicine
- Vol. 385 (23), 2200-2202
- https://doi.org/10.1056/nejmc2115772
Abstract
To the Editor: Bradbury et al. (Sept. 2 issue)1 designed the randomized, open-label FLIGHT trial to test the efficacy of mycophenolate mofetil plus glucocorticoids as compared with glucocorticoids alone in patients with immune thrombocytopenia (ITP). The authors conclude that mycophenolate mofetil plus glucocorticoids is a promising treatment. In previous studies, we have found that patients with ITP have a higher prevalence of other autoimmune diseases, such as systemic lupus erythematosus and Sjögren’s syndrome.2,3 We wonder whether some patients in the FLIGHT trial might have had subclinical autoimmune diseases, not only ITP. Before we generalize the results of this trial to . . .Keywords
This publication has 10 references indexed in Scilit:
- Mycophenolate Mofetil for First-Line Treatment of Immune ThrombocytopeniaThe New England Journal of Medicine, 2021
- Clinical Characteristics of Secondary Immune Thrombocytopenia Associated With Primary Sjögren's SyndromeFrontiers in Medicine, 2020
- Risk of systemic lupus erythematosus in patients with idiopathic thrombocytopenic purpura: a population-based cohort studyAnnals Of The Rheumatic Diseases, 2020
- Updated international consensus report on the investigation and management of primary immune thrombocytopeniaBlood Advances, 2019
- Trial protocol: a multicentre randomised trial of first-line treatment pathways for newly diagnosed immune thrombocytopenia: standard steroid treatment versus combined steroid and mycophenolate. The FLIGHT trialBMJ Open, 2018
- Validation of the FACIT-fatigue subscale, selected items from FACT-thrombocytopenia, and the SF-36v2 in patients with chronic immune thrombocytopeniaQuality of Life Research, 2011
- Health-related quality of life of immune thrombocytopenic purpura patients: results from a web-based surveyCurrent Medical Research and Opinion, 2008
- Subgroup analysis in randomised controlled trials: importance, indications, and interpretationThe Lancet, 2005
- Interpretation of Changes in Health-related Quality of LifeMedical Care, 2003
- SF-36 Health Survey UpdateSpine, 2000