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Revisiting a Meta-analysis Shows that Hydroxychloroquine with Azithromycin may be Efficient in Covid-19 patients

Valère Lounnas, Alexis Lacout, Xavier Azalbert, Christian Perronne
Published: 1 January 2021
Archives of Microbiology & Immunology , Volume 5, pp 154-175; doi:10.26502/ami.93650055

Abstract: Objective: To analyze the impact of study selection on the results of a recently published meta-analysis of the efficacy of hydroxychloroquine (HCQ) and hydroxychloroquine plus azithromycin (AZI) in Covid-19 patients. Methods: 31 studies were reviewed looking for critical bias. Combined hazard ratios and confidence intervals were calculated for both treatments using a fixed effects size model and a random effects model. Quantitative analysis regarding the toxicity of the association HCQ plus AZI is made. Results: Meta-analyses performed on the 11 studies we deem critically unbiased show a mortality reduction of 55% for HCQ and 66% for HCQ plus AZI. For both treatments, our meta-analysis indicates a significant efficacy in reducing mortality in hospitalized Covid-19 patients.
Keywords: mortality / Efficacy / model / treatments / hydroxychloroquine / meta / Hcq / plus / Azi / COVID

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