Obstetric, maternal, and neonatal outcomes in COVID-19 compared to healthy pregnant women in Iran: a retrospective, case-control study
Open Access
- 14 June 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Middle East Fertility Society Journal
- Vol. 26 (1), 1-8
- https://doi.org/10.1186/s43043-021-00059-2
Abstract
Background: The purpose of the present study was to evaluate obstetric, maternal, and neonatal outcomes in COVID-19 compared to healthy pregnant women in Iran.Results: A case-control study was conducted on 55 COVID-19 as the case and 55 matched control pregnant women in Hormozgan, Iran. Patients were considered to be cases if they had a positive COVID-19 test plus a positive chest X-ray result. Our measures were COVID-19 symptoms, including laboratory evaluations, clinical symptoms, and maternal and neonatal outcomes.The most prevalent symptoms related to COVID-19 were fever (69.09%) and cough (58.18%). Less common symptoms included fatigue, diarrhea, shortness of breath, sore throat, and myalgia. Hydroxychloroquine/chloroquine (58.18%) and antibiotic therapy (45.45%) were the most prevalent management in COVID-19 patients. Based on our findings, maternal and obstetric outcomes—neonatal in case groups—such as mode of delivery, premature rupture of membrane, postpartum hemorrhage, perineal resection rate, neonates’ birth weight, Apgar score, and neonatal asphyxia rate were similar to pregnant women without COVID-19. We observed a higher incidence rate of premature delivery in COVID-19 cases (25 vs. 10%) (p< 0.05). In the present study, we found that women with COVID-19 had a more than twofold increased odds of preterm labor. History of preterm delivery was also associated with high twofold odds of preterm labor.Conclusion: We observed a higher incidence rate of premature delivery in COVID-19 cases. Women with COVID-19 had a more than twofold increased odds of preterm labor. Considering prematurity has high morbidity and is regarded as the primary cause of mortality in children under 5 years old, more case-control studies are needed to ascertain the results.Keywords
This publication has 15 references indexed in Scilit:
- Coronavirus disease 2019 infection among asymptomatic and symptomatic pregnant women: two weeks of confirmed presentations to an affiliated pair of New York City hospitalsAmerican Journal of Obstetrics & Gynecology MFM, 2020
- Expert consensus for managing pregnant women and neonates born to mothers with suspected or confirmed novel coronavirus (COVID‐19) infectionInternational Journal of Gynecology & Obstetrics, 2020
- Maternal and Neonatal Outcomes of Pregnant Women With Coronavirus Disease 2019 (COVID-19) Pneumonia: A Case-Control StudyClinical Infectious Diseases, 2020
- [Analysis of the pregnancy outcomes in pregnant women with COVID-19 in Hubei Province].2020
- Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical recordsThe Lancet, 2020
- Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumoniaTranslational Pediatrics, 2020
- Prevalence of preterm labor in Iran: A systematic review and meta-analysisInternational Journal of Reproductive BioMedicine, 2015
- Born Too Soon: The global epidemiology of 15 million preterm birthsReproductive Health, 2013
- National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implicationsThe Lancet, 2012
- A case‐controlled study comparing clinical course and outcomes of pregnant and non‐pregnant women with severe acute respiratory syndromeBJOG: An International Journal of Obstetrics and Gynaecology, 2004