A comparison of behavioral and pharmacological interventions to attenuate reactivated fear memories
Open Access
- 17 July 2017
- journal article
- research article
- Published by Cold Spring Harbor Laboratory in Learning & Memory
- Vol. 24 (8), 369-374
- https://doi.org/10.1101/lm.045385.117
Abstract
Two experiments using rats in a contextual fear memory preparation compared two approaches to reduce conditioned fear: (1) pharmacological reconsolidation blockade and (2) reactivation-plus-extinction training. In Experiment 1, we explored different combinations of reactivation-plus-extinction parameters to reduce conditioned fear and attenuate reacquisition. In Experiment 2, memory reactivation was followed by extinction training or administration of midazolam (MDZ) (vs. vehicle) to reduce conditioned fear and attenuate spontaneous recovery. We found both treatments to be equally effective in both experiments. This study suggests that parameters leading to memory destabilization during reactivation are critical to observe long-lasting effects of MDZ or reactivation plus extinction.Funding Information
- SeCyT – Universidad Nacional de Córdoba
- CONICET
- Agencia Nacional de Promoción Científica y Tecnológica – FonCyT
- ERC (648176)
- KU Leuven
- CONICET
- SECYT
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