Regulation of Genomic Output and (Pluri)potency in Regeneration
- 3 December 2019
- journal article
- review article
- Published by Annual Reviews in Annual Review of Genetics
- Vol. 53 (1), 327-346
- https://doi.org/10.1146/annurev-genet-112618-043733
Abstract
Regeneration is a remarkable phenomenon that has been the subject of awe and bafflement for hundreds of years. Although regeneration competence is found in highly divergent organisms throughout the animal kingdom, recent advances in tools used for molecular and genomic characterization have uncovered common genes, molecular mechanisms, and genomic features in regenerating animals. In this review we focus on what is known about how genome regulation modulates cellular potency during regeneration. We discuss this regulation in the context of complex tissue regeneration in animals, from Hydra to humans, with reference to ex vivo–cultured cell models of pluripotency when appropriate. We emphasize the importance of a detailed molecular understanding of both the mechanisms that regulate genomic output and the functional assays that assess the biological relevance of such molecular characterizations. Expected final online publication date for the Annual Review of Genetics, Volume 53 is November 23, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.Keywords
This publication has 125 references indexed in Scilit:
- The history and enduring contributions of planarians to the study of animal regenerationWIREs Developmental Biology, 2012
- The Transcriptional and Epigenomic Foundations of Ground State PluripotencyCell, 2012
- Regeneration of Amputated Zebrafish Fin Rays from De Novo OsteoblastsDevelopmental Cell, 2012
- Bone Regenerates via Dedifferentiation of Osteoblasts in the Zebrafish FinDevelopmental Cell, 2011
- Slicing across Kingdoms: Regeneration in Plants and AnimalsCell, 2008
- Genetic dissection reveals two separate pathways for rod and cone regeneration in the teleost retinaDevelopmental Neurobiology, 2008
- High-Resolution Profiling of Histone Methylations in the Human GenomeCell, 2007
- Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined FactorsCell, 2006
- A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem CellsCell, 2006
- Identification of Genes Needed for Regeneration, Stem Cell Function, and Tissue Homeostasis by Systematic Gene Perturbation in PlanariaDevelopmental Cell, 2005