As a new theory of cultural heritage protection and research, cultural routes emphasize the inte-grity of culture and pay more attention to the interaction and integration between cultural com-munities along the route. The Ancient Tea-Horse Road is an important cultural, economic and re-ligious exchange link between the various ethnic groups in the Han and Tibetan two places. As the starting point of the line, Ya’an section plays an extremely important role. From the perspective of cultural route, this paper explores the cultural value of the Ya’an section of the Sichuan-Tibet Tea Horse Ancient Road with the idea of cultural integrity along the line, integrates the cultural elements along the line to form an integrated cultural industry cluster along the line, establishes the tea-horse ancient road cultural route heritage system and the management system of overall coordination and overall protection, deeply excavates the multiple values of the cultural industry along the line, promotes the coordinated development of the line, and empowers the rural revitalization along the line.