Endocan and Asymmetric Dimethylarginine as an Etiological Indicator in the Maternal and Umbilical Cord Serum in Pre-Eclampsia

Abstract

Aim: Preeclampsia is a pregnancy-specific disease of unknown etiology. This study was planned to determine the place of asymmetric dimethylarginine (N, N-dimethylarginine, ADMA) and endothelial cell specific molecule-1 (ESM1, endocan) levels in etiology. The aim of this study was to determine ADMA and endocan levels in maternal and fetal umbilical cord serum of patients with preeclampsia and to evaluate them with clinical data. Methods: This case-control study was conducted between June and December 2020. The clinical and demographic characteristics of the participants were evaluated in the department of obstetrics and gynecology. Thirty-tree women with preeclampsia and 55 healthy women in the same age group were included in our study. Serum ADMA and endocan values were determined by the ELISA method. Results: Maternal and umbilical cord ADMA levels in the preeclampsia group were statistically significantly higher than the control group (p=0.001, p=0.001, respectively). Likewise, the levels of the umbilical cord and maternal serum endocan were statistically significantly higher in the preeclampsia group compared to the control group (p=0.001, p=0.037, respectively). Conclusion: We found that ADMA and endocan molecules associated with endothelial dysfunction in the pathogenesis of preeclampsia significantly increased in maternal and umbilical cord serum.