Aflatoxin Biosynthesis and Genetic Regulation: A Review
Top Cited Papers
Open Access
- 28 February 2020
- Vol. 12 (3), 150
- https://doi.org/10.3390/toxins12030150
Abstract
The study of fungal species evolved radically with the development of molecular techniques and produced new evidence to understand specific fungal mechanisms such as the production of toxic secondary metabolites. Taking advantage of these technologies to improve food safety, the molecular study of toxinogenic species can help elucidate the mechanisms underlying toxin production and enable the development of new effective strategies to control fungal toxicity. Numerous studies have been made on genes involved in aflatoxin B1 (AFB1) production, one of the most hazardous carcinogenic toxins for humans and animals. The current review presents the roles of these different genes and their possible impact on AFB1 production. We focus on the toxinogenic strains Aspergillus flavus and A. parasiticus, primary contaminants and major producers of AFB1 in crops. However, genetic reports on A. nidulans are also included because of the capacity of this fungus to produce sterigmatocystin, the penultimate stable metabolite during AFB1 production. The aim of this review is to provide a general overview of the AFB1 enzymatic biosynthesis pathway and its link with the genes belonging to the AFB1 cluster. It also aims to illustrate the role of global environmental factors on aflatoxin production and the recent data that demonstrate an interconnection between genes regulated by these environmental signals and aflatoxin biosynthetic pathway.Keywords
This publication has 212 references indexed in Scilit:
- Oxidative Stress-Related Transcription Factors in the Regulation of Secondary MetabolismToxins, 2013
- Evidence that a transcription factor regulatory network coordinates oxidative stress response and secondary metabolism in aspergilliMicrobiologyopen, 2013
- Current Understanding on Aflatoxin Biosynthesis and Future Perspective in Reducing Aflatoxin ContaminationToxins, 2012
- Cross-talk between light and glucose regulation controls toxin production and morphogenesis in Aspergillus nidulansFungal Genetics and Biology, 2010
- Measurement of superoxide dismutase, catalase and glutathione peroxidase in cultured cells and tissueNature Protocols, 2009
- Functional expression and sub-cellular localization of the early aflatoxin pathway enzyme Nor-1 in Aspergillus parasiticusMycological Research, 2009
- Genetic regulation of aflatoxin biosynthesis: From gene to genomeFungal Genetics and Biology, 2009
- The VeA regulatory system and its role in morphological and chemical development in fungiFungal Genetics and Biology, 2008
- Production of cyclopiazonic acid, aflatrem, and aflatoxin by Aspergillus flavus is regulated by veA, a gene necessary for sclerotial formationApplied Microbiology and Biotechnology, 2007
- Biochemical analysis of oxidative stress in the production of aflatoxin and its precursor intermediatesMycopathologia, 2006