This study was conducted in order to see the relationship among work-life balance, self-esteem, and psychological well-being at work, especially in bank sector where work pressure is intense. 150 questionnaires were distributed to staff at banks in Banda Aceh City, Indonesia. The data analysis was calculated using SPSS 20. The results indicate that self-esteem affects significantly psychological well-being, meanwhile work-life balance enhances partially the affects between self-esteem and psychological well-being.