Thyroid carcinoma with thymus-like differentiation (CASTLE) tumor: а сase report
Open Access
- 8 August 2021
- journal article
- Published by Publishing House ABV Press in Head and Neck Tumors (HNT)
- Vol. 11 (2), 64-71
- https://doi.org/10.17650/2222-1468-2021-11-2-64-71
Abstract
Thyroid carcinoma with thymus-like differentiation (Carcinoma Showing Thymus-Like Differentiation, CASTLE) is an extremely rare disease. It arises from the thymus tissue ectopic into the tissue of the thyroid gland, usually in patients 40–50 years old. In this work, we present an observation of the development of CASTLE in a patient at a young age. A 21-year-old woman was admitted to our clinic with a volumetric education in the projection of the left lobe of the thyroid gland. Ultrasound revealed a 5-centimeter thyroid tumor. Surgery was performed in the scope of thyroidectomy, selective cervical dissection (level VI). Morphological and immunohistochemical studies showed that cancer has a thymus-like differentiation (CASTLE). After 32 months, she recurred to the lymph nodes of the neck (level IV on the left). She underwent repeated surgery, after which she was observed without signs of relapse for 120 months. The rarity of the pathology leads to difficulties in establishing a diagnosis at the preoperative stage and in choosing the optimal treatment tactics during treatment and further follow-up.This publication has 18 references indexed in Scilit:
- Thyroid Carcinoma Showing Thymus-Like ElementsAmerican Journal of Clinical Pathology, 2015
- Potential Role of Adjuvant Radiation Therapy in Cervical Thymic Neoplasm Involving Thyroid Gland or NeckCancer Research and Treatment, 2014
- Extrathyroid carcinoma showing thymus-like differentiation (CASTLE): a new case report and review of the therapeutic role of neck dissection and radiotherapyWorld Journal of Surgical Oncology, 2014
- Management of thyroid carcinoma showing thymus-like differentiation (CASTLE) invading the tracheaSurgery Today, 2013
- Sonographic findings in three cases of carcinoma showing thymus‐like differentiationJournal of Clinical Ultrasound, 2012
- FDG PET/CT of Carcinoma Showing Thymus-Like DifferentiationClinical Nuclear Medicine, 2012
- Cytologic Findings of Thyroid Carcinoma Showing Thymus-like Differentiation: A Case ReportThe Korean Journal of Pathology, 2012
- Extrathyroid carcinoma showing thymus-like differentiation (CASTLE) tumor—a new case report and review of literatureHead & Neck, 2005
- Carcinoma showing thymic-like elements—a rare malignancy of the thyroid glandBritish Journal of Surgery, 2004
- Intrathyroidal epithelial thymoma: An entity distinct from squamous cell carcinoma of the thyroidWorld Journal of Surgery, 1985