Possibilities of magnetic resonance imaging in SWI mode in differential diagnosis of brain gliomas (G3–G4) and primary lymphomas
Open Access
- 24 July 2020
- journal article
- Published by Publishing House ABV Press in Head and Neck Tumors (HNT)
- Vol. 10 (2), 38-45
- https://doi.org/10.17650/2222-1468-2020-10-2-38-45
Abstract
The study objectiveis to assess the possibilities of magnetic resonance imaging (MRI) in SWI (susceptibility weighted imaging) in the differential diagnosis of glial brain tumors and primary brain lymphomas.Materials and methods.Fifty-four patients with brain tumors were studied (men – 27 (50 %), women – 27 (50 %)). Average age 57.9 years. Histological examination of the surgical material revealed the glial nature of tumors in 41 patients (26 of them with glioblastoma, anaplastic astrocytomas – 15), primary brain lymphomas – in 13 patients. Brain MRI was performed using tomographs with a magnetic field of 3 and 1.5 T. A semi-quantitative assessment of the data obtained in the SWI mode based on the classification of ITSS (intratumoral susceptibility signals), reflecting the severity of interstitial vascular architectonics and microbleeding.Results.The degree of ITSS was 3 in glioblastomas (G4 ) in 26 (100 %) cases, in the structure of gliomas (G3 ) the ITSS values were 3 in 3 (20 %) cases, in the remaining 12 (80 %) cases – ITSS 2. In the group of primary brain lymphomas, the ITSS 1 was in 4 (30.7 %) cases, ITSS 0 was in 9 (69.3 %) cases.Conclusion.MRI in SWI mode is a promising technique that allows one to quantify the degree of pathological changes in tumor vascular architectonics and intratumoral hemorrhages and has shown high specificity in the differential diagnosis of malignant gliomas and lymphomas of the brain, accompanied by active accumulation of contrast medium.Keywords
This publication has 31 references indexed in Scilit:
- Differentiation of primary central nervous system lymphoma from high‐grade glioma and brain metastases using susceptibility‐weighted imagingBrain and Behavior, 2014
- Glioblastomas vs. Lymphomas: More Diagnostic Certainty by Using Susceptibility-Weighted Imaging (SWI)RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 2012
- New MR sequences in daily practice: susceptibility weighted imaging. A pictorial essayInsights into Imaging, 2011
- Combination of high-resolution susceptibility-weighted imaging and the apparent diffusion coefficient: added value to brain tumour imaging and clinical feasibility of non-contrast MRI at 3 TThe British Journal of Radiology, 2010
- Susceptibility-Weighted Imaging: Technical Aspects and Clinical Applications, Part 2American Journal of Neuroradiology, 2009
- Angiogenesis in primary central nervous system lymphoma (PCNSL)Journal of Neuro-Oncology, 2007
- Anti-Angiogenic and Anti-Inflammatory Effects of Statins: Relevance to Anti-Cancer TherapyCurrent Cancer Drug Targets, 2005
- Hemorrhage and VEGF Expression in a Case of Primary CNS LymphomaJournal of Neuro-Oncology, 2002
- Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failureNature Medicine, 1999
- A High Pretreatment Serum Vascular Endothelial Growth Factor Concentration Is Associated With Poor Outcome in Non-Hodgkin's LymphomaBlood, 1997