Transmission of Respiratory Syncytial Virus genotypes in Cali, Colombia
Open Access
- 8 April 2021
- journal article
- research article
- Published by Wiley in Influenza and Other Respiratory Viruses
- Vol. 15 (4), 521-528
- https://doi.org/10.1111/irv.12833
Abstract
Background Colombia's climatological variety, added to pathogen diversity, creates local niches for infectious diseases. In Bogotá, respiratory syncytial virus causes 30%‐52% of the cases of respiratory infections. In coastal or inter‐Andean cities with higher temperature and longer dry seasons, frequency of this virus is 7%‐13%. By 2017, increased hospitalizations due to airway infections occurred in regions whose weather is differently influenced by “El Niño Southern Oscillation” than in Bogotá, although microbial diversity might have also been involved. Methods For Cali, an inter‐Andean city with warm tropical weather, records of respiratory syncytial virus from 2014 to 2018, in children two years old or younger, were analyzed, and genotypes transmitted during 2016‐2017 were identified based on partial sequences of glycoprotein G. Results Most cases of respiratory syncytial virus in Cali occur in the first semesters, with peaks expressed around March‐April, without a clear association with pluviosity. Unlike the biannual rotating pattern of Bogotá, co‐circulation of types A and B was detected. As years pass, transmission seasons are becoming longer and frequencies of the virus augment. The viral genotypes identified follow international trends with dominance of Ontario and Buenos Aires clades. Similar to other isolates in these clades, viruses from Cali exhibit glycosylation variability that may account for their fitness. Conclusions The pattern of respiratory syncytial virus transmission in Cali differs from that in Bogotá. Its epidemiology is shifting and will remain so with the advent of novel respiratory diseases. This may impact the introduction of vaccination schemes for these or other respiratory viruses.Keywords
Funding Information
- Universidad del Valle (Bolsa concursable para fomento a publicacion)
This publication has 30 references indexed in Scilit:
- GlycoMine: a machine learning-based approach for predicting N-, C- and O-linked glycosylation in the human proteomeBioinformatics, 2015
- Novel Respiratory Syncytial Virus (RSV) Genotype ON1 Predominates in Germany during Winter Season 2012–13PLOS ONE, 2014
- Gene Sequence Variability of the Three Surface Proteins of Human Respiratory Syncytial Virus (HRSV) in TexasPLOS ONE, 2014
- Structure and Function of Respiratory Syncytial Virus Surface GlycoproteinsPublished by Springer Science and Business Media LLC ,2013
- Clinical and Epidemiologic Features of Respiratory Syncytial VirusPublished by Springer Science and Business Media LLC ,2013
- Respiratory syncytial virus infection as a cause of hospitalization in population under 1 year in ColombiaJornal de Pediatria, 2013
- The Natural History of Respiratory Syncytial Virus in a Birth Cohort: The Influence of Age and Previous Infection on Reinfection and DiseaseAmerican Journal of Epidemiology, 2012
- Emerging Genotypes of Human Respiratory Syncytial Virus Subgroup A among Patients in JapanJournal of Clinical Microbiology, 2009
- Effect of climatological factors on respiratory syncytial virus epidemicsEpidemiology and Infection, 2008
- Subgroup Prevalence and Genotype Circulation Patterns of Human Respiratory Syncytial Virus in Belgium during Ten Successive Epidemic SeasonsJournal of Clinical Microbiology, 2007