Genetic variants of COVID-19 and vaccination. Is there a Correlation?
- 11 February 2022
- journal article
- Published by Peertechz Publications Private Limited in Open Journal of Proteomics and Genomics
- Vol. 7 (1), 001-005
- https://doi.org/10.17352/ojpg.000011
Abstract
Background: New coronavirus disease is considered one of the most widely spreading viral infections all over the world. Increased numbers of severe covid-19 cases are growing up. Gene sequencing and discovering new viral variants is an essential aspect during the pandemic. The generation of treatment-resistant viral strains and the probability of negative impact on vaccination efficacy is possible. We aimed to review the probable effect of new variant emergence on treatment and vaccination efficacy, besides, the importance of gene sequencing from published literature data till the moment. Main body of the SARS-CoV-2 genome studies indicated that it shared 79 to 82% nucleotide similarity with SARS-CoV-1. Several gene locations in the envelope (E) structural protein c.222G>C (p. Leu74Leu) and the Membrane (M) structural protein c.213C>T (p. Tyr71Tyr) were proved to have mutations. Also, the surface (S) gene mutation c.1841A>G (p. Asp614Gly) is most relevant. The published sequences in Egypt are accounting for less than 0.2 percent of reported instances. Short conclusion: The possibility of rapid generation of treatment-resistant viral strains is highly possible. As a consequence of genetic alterations that impart functional differences in infectivity, sub-strains might arise as a result of acquired immunity that is likely to diminish over time and become less effective against increasingly aggressive strains. Gene sequencing in Egypt requires a lot of efforts to provide a rapid discovery for new emerging variants, to avoid a possible decrease in vaccination efficacy and emergence of treatment-resistant strains.Keywords
This publication has 35 references indexed in Scilit:
- Variant analysis of SARS-CoV-2 genomesBulletin of the World Health Organization, 2020
- Cryo-EM structure of the 2019-nCoV spike in the prefusion conformationScience, 2020
- SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease InhibitorCell, 2020
- The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2Nature Microbiology, 2020
- A Novel Coronavirus from Patients with Pneumonia in China, 2019The New England Journal of Medicine, 2020
- Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor bindingThe Lancet, 2020
- Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome CoronavirusJournal of Virology, 2016
- Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptorNature, 2013
- Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi ArabiaThe New England Journal of Medicine, 2012
- Identification of a Novel Coronavirus in Patients with Severe Acute Respiratory SyndromeThe New England Journal of Medicine, 2003