Inhibition of Platelet Adhesion from Surface Modified Polyurethane Membranes
Open Access
- 8 December 2020
- journal article
- Published by Biomedical Research Network, LLC in Biomedical Journal of Scientific & Technical Research
- Vol. 32 (3), 24988-24993
- https://doi.org/10.26717/bjstr.2020.32.005247
Abstract
Coronary thrombosis is one of the leading causes of mortality and morbidity in cardiovascular diseases, and patients who received vascular stent treatments are likely to suffer from restenosis due to tissue damage from stenting procedures (extrinsic pathway) and/or presence of unregulated factor XII (intrinsic pathway). Regardless of the pathway, coagulation factors and exposed collagen activate the G-protein-coupled receptors located at the plasma membrane of the resting platelets resulting in the change of their shapes with protrusions of filopodia and lamellipodia for surface adhesion. In this mini review, we discussed the mechanisms involved in platelet activation, adhesion, and aggregation. More importantly, we reviewed the use of polyurethane membranes with modified surface functional groups to down-regulate platelet adhesion and aggregation activities. Polyurethane membranes with hydrophilic and negatively charged surface properties showed a reduced αIIb-β3 signaling from the activated platelets, resulting in the decrease of platelet adhesion and aggregation. The use of polyurethane membranes with modified surface properties as coatings on vascular stents provides an engineering approach to mitigate blood clotting associated with restenosis.Keywords
This publication has 26 references indexed in Scilit:
- Thermal and Physico-Mechanical Characterizations of Thromboresistant Polyurethane FilmsBioengineering, 2019
- Dual role of collagen in factor XII–dependent thrombus formationBlood, 2009
- Activation of Platelet Function Through G Protein–Coupled ReceptorsCirculation Research, 2006
- Fibrinogen surface distribution correlates to platelet adhesion pattern on fluorinated surface-modified polyetherurethaneBiomaterials, 2005
- Fibrin Proliferation at Model Surfaces: Influence of Surface PropertiesLangmuir, 2005
- Actin dynamics in plateletsInternational Review of Cytology, 2002
- How the protease thrombin talks to cellsProceedings of the National Academy of Sciences of the United States of America, 1999
- The human platelet ADP receptor activates Gi2 proteinsBiochemical Journal, 1995
- Identification of Gq as one of the G-proteins which copurify with human platelet thromboxane A2/prostaglandin H2 receptors.1993
- The mechanism of the effect of aspirin on human platelets. I. Acetylation of a particulate fraction protein.JCI Insight, 1975