Study on the Effect of Berberine on the Proliferation of Helicobacter pylori

Abstract

Objective: To study the inhibitory effect of berberine on the proliferation of Helicobacter pylori and its mechanism, so as to provide a new experimental basis for the treatment of gastritis. Methods: The minimal inhibitory concentration (MIC) of berberine against Helicobacter pylori and the inhibitory effect of berberine combined with metronidazole and clarithromycin at different concentrations on Helicobacter pylori were determined by incremental concentration method. Results: The MIC of Helicobacter pylori strains 26,695, S1 and 11,637 against berberine were 32 μg/ml, 32 μg/ml and 8 μg/ml, respectively. Combined bacteriostasis: MIC of Helicobacter pylori strain 26,695, strain Ss1 and strain 11,637 were berberine 16 μg/ml combined with metronidazole 4 μg/ml, berberine 8 μg/ml combined with metronidazole 4 μg/ml, and berberine 4 μg/ml combined with metronidazole 2 μg/ml, respectively. Conclusion: Berberine can successfully inhibit the proliferation of Helicobacter pylori , and the combination of drug resistance and bacteriostasis is obvious.