A study was conducted to determine the response of several varieties of large chilli (Capsicum annuum L.) to Trichoderma enrichment on planting media and Boron fertilizer applications. The study was conducted from June to September 2017 at the Experimental Garden of the Faculty of Agriculture, Hasanuddin University, Makassar in the form of factorial Split Plot Design with 2 factors. Experiments were set with large chili varieties as the main plot consisting of var. Karina, var. Tombak, and var. Panex 100 F1, while the combination of Trichoderma enrichment and Boron fertilizer was set as subplots consist of 6 treatment combinations. The results show that there was a significant interaction between the treatment of varieties and Trichoderma-Boron on plant height parameter and there was a significant effect of the varieties treatment on the number of productive branches and the number of fruits per plant. In addition, significant effect of the Trichoderma-Boron treatment was shown in the parameters of fruit length per plant 100 HST. The interaction that gave the best results was in the treatment of Trichoderma asperellum 4 g plant-1 and Panex 100 F1 varieties on plant height of 47.77 cm. The treatment of varieties that gave the best results was Karina variety and the combination treatment of Trichoderma-Boron that gave the best results was the treatment of Trichoderma asperellum 4 g plant-1 + Boron 1 mg L-1. Keywords: Capsicum annuum L., microbe, boron fertilizer, varieties ABSTRAK Penelitian dilaksanakan untuk mengetahui respon beberapa varietas cabai besar (Capsicum annuum L.) terhadap pengayaan Trichoderma pada media tanam dan aplikasi pupuk Boron. Penelitian berlangsung dari bulan Juni-September 2017 di Kebun Percobaan Fakultas Pertanian Universitas Hasanuddin, Makassar dan dilaksanakan dalam bentuk percobaan Rancangan Petak Terpisah dalam rancangan acak kelompok faktorial dengan 2 faktor. Percobaan diatur dengan varietas cabai besar sebagai petak utama yaitu varietas Karina (V1), varietas Tombak (V2), dan varietas Panex 100 F1(V3) sedangkan kombinasi cendawan Trichoderma dan pemupukan Boron sebagai anak petak terdiri atas 6 kombinasi perlakuan. Penelitian menunjukkan interaksi yang nyata antara perlakuan varietas dan Trichoderma-Boron pada parameter tinggi tanaman dan terdapat pengaruh nyata dari perlakuan varietas terhadap jumlah cabang produktif dan jumlah buah per tanaman. Pengaruh nyata dari perlakuan Trichoderma-Boron ditunjukkan pada parameter panjang buah per tanaman umur 100 HST. Interaksi yang memberikan hasil terbaik yaitu pada perlakuan Trichoderma asperellum 4 g tan-1 dan varietas Panex 100 F1 pada tinggi tanaman yaitu 47.77 cm. Perlakuan varietas memberikan hasil terbaik pada varietas Karina dan perlakuan kombinasi Trichoderma-Boron memberikan hasil terbaik pada perlakuan Trichoderma asperellum 4 g tan-1 + Boron 1 mg L-1. Kata kunci: Capsicum annuum L., mikroba, pupuk boron, varietas