Microwave-assisted solvent free efficient synthesis of 1,3,4-oxadiazole-2(3H)-thiones and their potent in vitro urease inhibition activity
Open Access
- 30 June 2012
- journal article
- Published by European Journal of Chemistry in European Journal of Chemistry
- Vol. 3 (2), 143-146
- https://doi.org/10.5155/eurjchem.3.2.143-146.551
Abstract
An efficient solvent free microwave assisted synthesis of 5-substituted-1,3,4-oxadiazole-2(3H)-thiones (2a-2r) from hydrazides and carbon disulfide has been accomplished in good to excellent yield. The urease inhibition activity of the resulting compounds was investigated. Preliminary bioassay indicated that the compound 2j bearing 2-bromo substituent is the most active inhibitor exhibiting IC50 12.60 ± 0.92 μM.Keywords
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