Ferrous Complexes with Bis (Meo) in Α-Substituted Tris (Pyridin-2-Ylmethyl) Amine Ligands: Effect of the Bis (Meo) in Α- Substituents in Dioxygen Activation and Biomimetic Reactivity
Open Access
- 10 October 2021
- journal article
- Published by Lattice Science Publication (LSP) in Indian Journal of Advanced Chemistry
- Vol. 1 (2), 20-26
- https://doi.org/10.54105/ijac.b2009.101221
Abstract
This report describes how the coordination of FeCl2 with tris(pyridin-2-ylmethyl)amine (TPA) ligands offers the possibilty to activate the molecular dioxygen in biomimetic processes. . It includes all procedures taken to the case for major oxidation reactions carried out in Nature under particular conditions. The aim of the this paper is to present the outcome of a thorough study for complex coordinations with ligands substituted by groups known as electron donors. It demonstrates how ligands with methoxy substituents are likely to be demethylated, and therefore providing entities potentially useful in synthesis. Targeting in modulating the electronic properties at the metal center, a new type of ligand (MeO)2TPA has been prepared and the complex of (MeO)2TPAFeCl2 has been studied by uv-visble ; 1H RMN paramagnatic and conductometry. The effect of (MeO) group in α-substituted on the structure as well as the effect of substitution on the oxygenation of the complex has been verified. Afterwards, the reactivity of the complex towards molecular dioxygen in absence of substrat is checked by uv-visble, 1H RMN paramagnatic and radiocristallography. As well, the reactivity in presence of substrat is tested.Keywords
This publication has 40 references indexed in Scilit:
- Easy Preparation of the Tris(2-fluoro-6-pyridylmethyl)amine Ligand and Instantaneous Reaction of the Corresponding Dichloroferrous Complex with Molecular Dioxygen: New Access to Dinuclear SpeciesInorganic Chemistry, 2004
- Trigonal Bipyramidal Geometry and Tridentate Coordination Mode of the Tripod in FeCl2 Complexes with Tris(2-pyridylmethyl)amine Derivatives Bis-α-Substituted with Bulky Groups. Structures and Spectroscopic Comparative StudiesInorganic Chemistry, 2002
- Modeling Rieske Dioxygenases: The First Example of Iron-Catalyzed Asymmetric cis-Dihydroxylation of OlefinsJournal of the American Chemical Society, 2001
- Circular Dichroism and Magnetic Circular Dichroism Spectroscopy of the Catalytically Competent Ferrous Active Site of Phenylalanine Hydroxylase and Its Interaction with Pterin CofactorJournal of the American Chemical Society, 1999
- Oxygen-18 Kinetic Isotope Effect Studies of the Tyrosine Hydroxylase Reaction: Evidence of Rate Limiting Oxygen ActivationJournal of the American Chemical Society, 1998
- Synthesis of novel chromeno[3,4-b]pyridinonesJournal of the Chemical Society, Perkin Transactions 1, 1998
- Models for .alpha.-Keto Acid-Dependent Non-heme Iron Enzymes: Structures and Reactivity of [FeII(L)(O2CCOPh)](ClO4) ComplexesJournal of the American Chemical Society, 1995
- Recent investigations into the lipoxygenase pathway of plantsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1991
- Mechanism of oxygen activation by tyrosine hydroxylaseBiochemistry, 1987
- Phenylalanine hydroxylase: absolute configuration and source of oxygen of the 4a-hydroxytetrahydropterin speciesBiochemistry, 1985