The low rainfall and high temperature greatly affect the decline in production and quality of forage in general. The experiment was arranged in a completely randomized design with two factors and four replications. The first factor consisted of 3 level of drought stress namely: 100% field capacity (FC) (control), 50% FC, and 25% FC. The second factor comprised of 3 defoliation interval i.e. interval defoliations of 60, 90 and 120 days. The observed variables were nutrient content (crude protein (CP), crude fibre (CF), Gross energy, lignin, selulose, neutral/acid detergent fibre (NDF/ADF), in vitro dry matter and organic matter digestibility (IVMD/IVOMD), Ash, Ca and P) and anti-nutrient content (Tannin and Saponin). Data were analyzed by ANOVA and the differences between treatments were tested by LSD. The results shows that there were interactions (PKey Words: I. zollingeriana, Drought Stress, Defoliation Interval, Nutrient, Anti-Nutrients