Viruses teach T cells to tackle tumors

Publisher Website

11 September 2019

journal article
Published by American Association for the Advancement of Science (AAAS) in Science Translational Medicine

Vol. 11 (509), eaaz0309
https://doi.org/10.1126/scitranslmed.aaz0309

Abstract

Oncolytic vaccinia virus expressing leptin enhances T cell clearance of melanomas.

Keywords

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Oncolytic Viruses Engineered to Enforce Leptin Expression Reprogram Tumor-Infiltrating T Cell Metabolism and Promote Tumor Clearance
Immunity, 2019