Glycan Nanostructures of Human Coronaviruses
Open Access
- 1 July 2021
- journal article
- review article
- Published by Taylor & Francis Ltd in International Journal of Nanomedicine
- Vol. ume 16, 4813-4830
- https://doi.org/10.2147/ijn.s302516
Abstract
Human coronaviruses present a substantial global disease burden, causing damage to populations’ health, economy, and social well-being. Glycans are one of the main structural components of all microbes and organismic structures, including viruses—playing multiple essential roles in virus infection and immunity. Studying and understanding virus glycans at the nanoscale provide new insights into the diagnosis and treatment of viruses. Glycan nanostructures are considered potential targets for molecular diagnosis, antiviral therapeutics, and the development of vaccines. This review article describes glycan nanostructures (eg, glycoproteins and glycolipids) that exist in cells, subcellular structures, and microbes. We detail the structure, characterization, synthesis, and functions of virus glycans. Furthermore, we describe the glycan nanostructures of different human coronaviruses, such as human coronavirus 229E (HCoV-229E), human coronavirus OC43 (HCoV-OC43), severe acute respiratory syndrome-associated coronavirus (SARS-CoV), human coronavirus NL63 (HCoV-NL63), human coronavirus HKU1 (HCoV-HKU1), the Middle East respiratory syndrome-associated coronavirus (MERS-CoV), and how glycan nanotechnology can be useful to prevent and combat human coronaviruses infections, along with possibilities that are not yet explored.Keywords
This publication has 114 references indexed in Scilit:
- A systematic study of the N-glycosylation sites of HIV-1 envelope protein on infectivity and antibody-mediated neutralizationRetrovirology, 2013
- Antigenic Subversion: A Novel Mechanism of Host Immune Evasion by Ebola VirusPLoS Pathogens, 2012
- Structural Bases of Coronavirus Attachment to Host Aminopeptidase N and Its Inhibition by Neutralizing AntibodiesPLoS Pathogens, 2012
- Mechanisms of Coronavirus Cell Entry Mediated by the Viral Spike ProteinViruses, 2012
- High-Dose Mannose-Binding Lectin Therapy for Ebola Virus InfectionThe Journal of Infectious Diseases, 2011
- Identification of N-linked carbohydrates from severe acute respiratory syndrome (SARS) spike glycoproteinVirology, 2010
- RETRACTED: Spike Protein, S, of Human Coronavirus HKU1: Role in Viral Life Cycle and Application in Antibody DetectionExperimental Biology and Medicine, 2008
- The Novel Human Coronaviruses NL63 and HKU1Journal of Virology, 2007
- Mature Glycoprotein G Presents High Performance in Diagnosing Herpes Simplex Virus Type 2 Infection in Sera of Different Tanzanian CohortsClinical and Vaccine Immunology, 2006
- An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirusNature Medicine, 2004