Molecular Mechanisms of the SLC13A5 Gene Transcription
Open Access
- 15 October 2021
- journal article
- review article
- Published by MDPI AG in Metabolites
- Vol. 11 (10), 706
- https://doi.org/10.3390/metabo11100706
Abstract
Citrate is a crucial energy sensor that plays a central role in cellular metabolic homeostasis. The solute carrier family 13 member 5 (SLC13A5), a sodium-coupled citrate transporter highly expressed in the mammalian liver with relatively low levels in the testis and brain, imports citrate from extracellular spaces into the cells. The perturbation of SLC13A5 expression and/or activity is associated with non-alcoholic fatty liver disease, obesity, insulin resistance, cell proliferation, and early infantile epileptic encephalopathy. SLC13A5 has been proposed as a promising therapeutic target for the treatment of these metabolic disorders. In the liver, the inductive expression of SLC13A5 has been linked to several xenobiotic receptors such as the pregnane X receptor and the aryl hydrocarbon receptor as well as certain hormonal and nutritional stimuli. Nevertheless, in comparison to the heightened interest in understanding the biological function and clinical relevance of SLC13A5, studies focusing on the regulatory mechanisms of SLC13A5 expression are relatively limited. In this review, we discuss the current advances in our understanding of the molecular mechanisms by which the expression of SLC13A5 is regulated. We expect this review will provide greater insights into the regulation of the SLC13A5 gene transcription and the signaling pathways involved therein.Funding Information
- National Institutes of Health (GM121550, CA262084)
This publication has 97 references indexed in Scilit:
- Deletion of the Mammalian INDY Homolog Mimics Aspects of Dietary Restriction and Protects against Adiposity and Insulin Resistance in MiceCell Metabolism, 2011
- Post-translational modification of pregnane x receptorPharmacological Research, 2011
- Acetylation of pregnane X receptor protein determines selective function independent of ligand activationBiochemical and Biophysical Research Communications, 2011
- Gene expression patterns in bone following mechanical loadingJournal of Bone and Mineral Research, 2010
- Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CARAdvanced Drug Delivery Reviews, 2010
- Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesisNature Medicine, 2010
- A Novel Role for the Dioxin Receptor in Fatty Acid Metabolism and Hepatic SteatosisGastroenterology, 2010
- Elucidating the ‘Jekyll and Hyde’ Nature of PXR: The Case for Discovering Antagonists or Allosteric AntagonistsPharmaceutical Research, 2009
- G‐protein signalling negatively regulates the stability of aryl hydrocarbon receptorEMBO Reports, 2009
- Nuclear Pregnane X Receptor Cross-talk with FoxA2 to Mediate Drug-induced Regulation of Lipid Metabolism in Fasting Mouse LiverOnline Journal of Public Health Informatics, 2007