| The research has been conducted to determine the changes in haematological and serum biochemical attributes in calves affected with navel ill. Peripheral blood was collected from affected and healthy calves, and serum was separated for biochemical evaluation. In term of haematological profile, Hb and TEC were decreased whereas PCV and TLC were elevated compared to healthy calves. Some leading enzymes such as ALT, AST, ALP, LDH, CK were elevated in affected calves than their healthy counterparts. Creatinine, BUN, LDL, HDL, cholesterol and triglyceride were also elevated remarkably. Mild alterations of electrolytes such as Na+, K+, Cl- and Ca+2 were also observed. The results demonstrated that navel ill may compromise vital organs which should be promptly treated once diagnosed. To prevent infection, navel area should be dipped with mild antiseptic and monitored regularly.