The pharmacokinetics of the injectable dosage form of GK-2 in rabbits
Open Access
- 1 December 2020
- journal article
- Published by Publishing House OKI in Pharmacokinetics and Pharmacodynamics
- No. 2,p. 17-21
- https://doi.org/10.37489/2587-7836-2020-2-17-21
Abstract
The pharmacokinetics of the nerve growth factor mimetic GK-2 (dimeric dipeptide mimetic of the 4-th loop NGF, a derivative of fluoro-substituted 5-[2-(5-fluoropyrid-3-yl) -ethyl)]-2,8-dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole) in rabbits after a single intravenous injection of an injectable dosage form at dose 24 mg (7,8-8,7 mg/kg). GK-2 concentrations in the blood plasma were determined by high-performance liquid chromatography with massspectrometric detection. GK-2 can be attributed to "short-lived" drugs, since the half-life from the rabbits blood plasma was 0.9±0.1 h.Keywords
This publication has 2 references indexed in Scilit:
- Improving the Accuracy of Predicted Human Pharmacokinetics: Lessons Learned from the AstraZeneca Drug Pipeline Over Two DecadesTrends in Pharmacological Sciences, 2020
- A Novel Dimeric Dipeptide Mimetic of the Nerve Growth Factor Exhibits Pharmacological Effects upon Systemic Administration and Has No Side Effects Accompanying the Neurotrophin TreatmentNeuroscience and Medicine, 2014