Severe psychiatric disorders and general medical comorbidities: inflammation-related mechanisms and therapeutic opportunities
- 5 September 2022
- journal article
- review article
- Published by Portland Press Ltd. in Clinical Science
- Vol. 136 (17), 1257-1280
- https://doi.org/10.1042/cs20211106
Abstract
Individuals with severe psychiatric disorders, such as mood disorders and schizophrenia, are at increased risk of developing other medical conditions, especially cardiovascular and metabolic diseases. These medical conditions are underdiagnosed and undertreated in these patients contributing to their increased morbidity and mortality. The basis for this increased comorbidity is not well understood, possibly reflecting shared risks factors (e.g. lifestyle risk factors), shared biological mechanisms and/or reciprocal interactions. Among overlapping pathophysiological mechanisms, inflammation and related factors, such as dysbiosis and insulin resistance, stand out. Besides underlying the association between psychiatric disorders and cardiometabolic diseases, these mechanisms provide several potential therapeutic targets.Keywords
This publication has 230 references indexed in Scilit:
- The prevalence of depression in rheumatoid arthritis: a systematic review and meta-analysisRheumatology, 2013
- The Hallmarks of AgingCell, 2013
- Long-term lithium treatment in bipolar disorder is associated with longer leukocyte telomeresTranslational Psychiatry, 2013
- Citalopram improves metabolic risk factors among high hostile adults: Results of a placebo-controlled interventionPsychoneuroendocrinology, 2011
- A Review of Treating Depression in Diabetes: Emerging FindingsPsychosomatics, 2011
- Metformin for olanzapine‐induced weight gain: a systematic review and meta‐analysisBritish Journal of Clinical Pharmacology, 2011
- Prevalence of mood and anxiety disorders in women with systemic lupus erythematosusArthritis Care & Research, 2009
- Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major DepressionBiological Psychiatry, 2009
- Human gut microbiota in obesity and after gastric bypassProceedings of the National Academy of Sciences of the United States of America, 2009
- Cytokine-effects on glucocorticoid receptor function: Relevance to glucocorticoid resistance and the pathophysiology and treatment of major depressionBrain, Behavior, and Immunity, 2007