Antioxidants and Atherosclerosis: Mechanistic Aspects
Top Cited Papers
Open Access
- 25 July 2019
- journal article
- review article
- Published by MDPI AG in Biomolecules
- Vol. 9 (8), 301
- https://doi.org/10.3390/biom9080301
Abstract
Atherosclerosis is a chronic inflammatory disease which is a major cause of coronary heart disease and stroke in humans. It is characterized by intimal plaques and cholesterol accumulation in arterial walls. The side effects of currently prescribed synthetic drugs and their high cost in the treatment of atherosclerosis has prompted the use of alternative herbal medicines, dietary supplements, and antioxidants associated with fewer adverse effects for the treatment of atherosclerosis. This article aims to present the activity mechanisms of antioxidants on atherosclerosis along with a review of the most prevalent medicinal plants employed against this multifactorial disease. The wide-ranging information in this review article was obtained from scientific databases including PubMed, Web of Science, Scopus, Science Direct and Google Scholar. Natural and synthetic antioxidants have a crucial role in the prevention and treatment of atherosclerosis through different mechanisms. These include: The inhibition of low density lipoprotein (LDL) oxidation, the reduction of reactive oxygen species (ROS) generation, the inhibition of cytokine secretion, the prevention of atherosclerotic plaque formation and platelet aggregation, the preclusion of mononuclear cell infiltration, the improvement of endothelial dysfunction and vasodilation, the augmentation of nitric oxide (NO) bioavailability, the modulation of the expression of adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) on endothelial cells, and the suppression of foam cell formation.Keywords
This publication has 160 references indexed in Scilit:
- Resveratrol ameliorates high-glucose-induced hyperpermeability mediated by caveolae via VEGF/KDR pathwayGenes & Nutrition, 2012
- Anti-Atherogenic Activity of Ethanolic Fraction ofTerminalia arjunaBark on Hypercholesterolemic RabbitsEvidence-Based Complementary and Alternative Medicine, 2011
- Overexpression of antioxidant enzymes in ApoE-deficient mice suppresses Benzo(a)pyrene-accelerated atherosclerosisAtherosclerosis, 2009
- Redox Regulation of Cell Survival by the Thioredoxin Superfamily: An Implication of Redox Gene Therapy in the HeartAntioxidants and Redox Signaling, 2009
- Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potentialBiochimica et Biophysica Acta (BBA) - General Subjects, 2009
- Reactive oxygen species, reactive nitrogen species and antioxidants in etiopathogenesis of diabetes mellitus type-2Indian Journal of Clinical Biochemistry, 2009
- Free radicals and antioxidants in normal physiological functions and human diseaseThe International Journal of Biochemistry & Cell Biology, 2007
- Glutathione, Stress Responses, and Redox Signaling in Lung InflammationAntioxidants and Redox Signaling, 2005
- The pathogenesis of atherosclerosis: a perspective for the 1990sNature, 1993
- Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.Proceedings of the National Academy of Sciences of the United States of America, 1981