Geometric constraints on human brain function
Open Access
- 5 October 2022
- preprint content
- research article
- Published by Cold Spring Harbor Laboratory
Abstract
The brain’s anatomy constrains its function, but precisely how remains unclear. Here, we show that human cortical and subcortical activity, measured with magnetic resonance imaging under spontaneous and diverse task-evoked conditions, can be parsimoniously understood as resulting from excitations of fundamental, resonant modes of the brain’s geometry (i.e., its shape) rather than of its complex inter-regional connectivity, as classically assumed. We then use these modes to show that task-evoked activations across >10,000 brain maps are not confined to focal areas, as widely believed, but instead excite brain-wide modes with wavelengths spanning >60 mm. Finally, we confirm theoretical predictions that the close link between geometry and function is explained by a dominant role for wave-like dynamics, showing that such dynamics can reproduce numerous canonical spatiotemporal properties of spontaneous and evoked recordings. Our findings challenge prevailing views of brain function and identify a previously under-appreciated role of brain geometry that is predicted by a unifying and physically principled approach. One-Sentence Summary The physical geometry of the brain fundamentally constrains the functional organization of the human brain.Keywords
This publication has 78 references indexed in Scilit:
- FreeSurferNeuroImage, 2012
- High-cost, high-capacity backbone for global brain communicationProceedings of the National Academy of Sciences of the United States of America, 2012
- Mapping Human Cortical AreasIn VivoBased on Myelin Content as Revealed by T1- and T2-Weighted MRIJournal of Neuroscience, 2011
- Spatiotemporal dynamics of low frequency BOLD fluctuations in rats and humansNeuroImage, 2011
- Greater than the sum of its parts: a review of studies combining structural connectivity and resting-state functional connectivityBrain Structure and Function, 2009
- The Dynamic Brain: From Spiking Neurons to Neural Masses and Cortical FieldsPLoS Computational Biology, 2008
- A Hierarchy of Temporal Receptive Windows in Human CortexJournal of Neuroscience, 2008
- Network structure of cerebral cortex shapes functional connectivity on multiple time scalesProceedings of the National Academy of Sciences of the United States of America, 2007
- High-resolution intersubject averaging and a coordinate system for the cortical surfaceHuman Brain Mapping, 1999
- Separate visual pathways for perception and actionTrends in Neurosciences, 1992