Controlling Effects of Astrocyte on Neuron Behavior in Tripartite Synapse Using VHDL–AMS
Open Access
- 25 October 2021
- journal article
- research article
- Published by MDPI AG in Mathematics
- Vol. 9 (21), 2700
- https://doi.org/10.3390/math9212700
Abstract
Astrocyte cells form the largest cell population in the brain and can influence neuron behavior. These cells provide appropriate feedback control in regulating neuronal activities in the Central Nervous System (CNS). This paper presents a set of equations as a model to describe the interactions between neurons and astrocyte. A VHDL–AMS-based tripartite synapse model that includes a pre-synaptic neuron, the synaptic terminal, a post-synaptic neuron, and an astrocyte cell is presented. In this model, the astrocyte acts as a controller module for neurons and can regulates the spiking activity of them. Simulation results show that by regulating the coupling coefficients of astrocytes, spiking frequency of neurons can be reduced and the activity of neuronal cells is modulated.Keywords
Funding Information
- Friedrich Schiller University Jena (433052568)
- Deanship of Scientific Research (DSR) at King Abdulaziz University, Jeddah, Saudi Arabia (FP-13-43)
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