Impact of Intestinal Microbiota on Quality of Life (QoL) of Hemodialysis Patients

Abstract

Chronic kidney disease is a global problem. Increasing evidence suggests that interstinal microflore is altered in patients with Chronic Kidney Disease (CKD).The gut microbiome is a key driver of chronic inflammation. Many of uremic retention solutes are produced by dysbiotic intestinal microflore that may have a great impact on survival of the CKD patients. Our sample study consisted of 147 patients (78 female, 69 male age 18-75) undergoing hemodialysis in one dialysis center. Data were collected by the completion of a scpecially designed questionnaire. Patients received hemodialysis therapy for 4-5 hours sessions, three times weekly using polysulfone dialyzers. It was revealed significant alteration of the colonic bacterial flora in hemodialysis patients, with the excess of the uremic toxin producing bacteria. Also, there was strict correlation between gut dysbiosis and HD patent's QoL.