The Effect of OPRM1 rs648893 Gene Polymorphism on Opioid Addiction in an Iranian population in Zabol: A Case-Control Study
Open Access
- 31 December 2019
- journal article
- Published by Maad Rayan Publishing Company in International Journal of Basic Science in Medicine
- Vol. 4 (4), 143-147
- https://doi.org/10.34172/ijbsm.2019.04
Abstract
Introduction: Opioid addiction (OA) is a neurologically life-threatening challenge associated with socioeconomic and health concerns for individuals and society. The addictive drugs trigger neuromodulators and neurotransmitters through the opioid receptors and corresponding endogenous peptide ligands. In addition, drug addiction is reportedly related to the mu-opioid receptor (OPRM1) encoding gene and its variants. According to the role of the rs648893 polymorphism of the OPRM1 gene in numerous disorders, it has been suggested as a candidate associated with drug addiction. The present case-control study was conducted to evaluate the role of OPRM1 rs648893 polymorphism in the OA risk. Methods: To this end, the rs648893 polymorphism was genotyped by tetra amplification refractory mutation system-polymerase chain reaction among 160 Iranian subjects consisting of 105 OA cases and 155 controls. Results: According to our findings, there was no significant association between OA and the OPRM1 rs648893 gene polymorphism. Moreover, a marginally insignificant difference was found between OA cases and controls in accordance with the allelic frequencies (P=0.05) Conclusion: In general, our results reported no association between OPRM1 rs648893 gene polymorphism and OA although further research among various ethnicities with larger sample sizes is needed to draw a definite conclusion on the association of rs648893 polymorphism and other OPRM1 intronic variants with opioid and other addictions.Keywords
This publication has 27 references indexed in Scilit:
- Association study of OPRM1 polymorphisms with Schizophrenia in Han Chinese populationBMC Psychiatry, 2013
- Opiate addiction and cocaine addiction: underlying molecular neurobiology and geneticsJCI Insight, 2012
- Pain Mechanisms in Patients with Chronic PainClinical Drug Investigation, 2012
- A novel SNP in COMT is associated with alcohol dependence but not opiate or nicotine dependence: a case control studyBehavioral and Brain Functions, 2011
- Variation in OPRM1 and Risk of Suicidal Behavior in Drug‐Dependent IndividualsThe American Journal on Addictions, 2011
- Opium Consumption and the Risk of Traffic Injuries in Regular Users: A Case-Crossover Study in an Emergency DepartmentTraffic Injury Prevention, 2009
- The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence riskMolecular Psychiatry, 2007
- The opioid system in alcohol and drug dependence: Family‐based association studyNeuropsychiatric Genetics, Part B of the American Journal of Medical Genetics (AJMG), 2007
- Association between two µ-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependenceHuman Molecular Genetics, 2006
- Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addictionNature Neuroscience, 2005